Doran584Lec2-S12

Doran584Lec2-S12 - Medical Microbiology Kelly Doran BIOL...

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Unformatted text preview: Medical Microbiology Kelly Doran BIOL 584 Spring 12 Host Response: Innate Immunity Schaechter ch 6 Microbiology: An Evolving Science 2009 W. W. Norton & Company, Inc. 2 Case Study Two tourists visiting the Alabama gulf coast take a swim in the Gulf of Mexico One a 12yr old girl cut her leg with the sharp edge of a scooter One a 66yr old man recently cut his arm on a protruding nail of a wooden handrail Within moments of swimming in the Gulf, several gram-negative microbes invade the body through the cuts Four days later, the young girl is heading back home, oblivious to the battle recently waged in her bloodstream The man lies dead of an aggressive blood infection. Both swimmers were attacked by the same pathogen, Vibrio vulnificus why did one die and one live? Microbiology: An Evolving Science 2009 W. W. Norton & Company, Inc. 2 Case Study Two tourists visiting the Alabama gulf coast take a swim in the Gulf of Mexico One a 12yr old girl cut her leg with the sharp edge of a scooter One a 66yr old man recently cut his arm on a protruding nail of a wooden handrail Within moments of swimming in the Gulf, several gram-negative microbes invade the body through the cuts Four days later, the young girl is heading back home, oblivious to the battle recently waged in her bloodstream The man lies dead of an aggressive blood infection. Both swimmers were attacked by the same pathogen, Vibrio vulnificus why did one die and one live? Microbiology: An Evolving Science 2009 W. W. Norton & Company, Inc. 3 Lecture Outline/Learning Objectives Innate Immune System Physical Defenses Cellular Defenses Other Defenses 4 Overview of the Immune System Innate Immunity Barriers to infection Nonspecific reaction to destroy invading cells Adaptive Immunity Reaction to specific antigens Parts of foreign proteins, sugars, chemicals Body reacts to antigens when exposed Retains memory of those antigens Faster response if exposed a second time protects us from being overrun by microbes 5 No innate immune system Innate immune system: First Line of Defense No adaptive immune system...
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Doran584Lec2-S12 - Medical Microbiology Kelly Doran BIOL...

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