1106Topic2 2011 - Topic 2: THE INTEGUMENTARY SYSTEM Chapter...

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Topic 2: THE INTEGUMENTARY SYSTEM Chapter 5
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2.1 Describe the layers of the epidermis and the cells that compose them “Would you be enticed by an advertisement for a coat that is waterproof, stretchable, washable, and permanent-press, that invisibly repairs small cuts, rips and burns and that is guaranteed to last a lifetime with reasonable care?” = skin + derivatives The Structure of Skin 2 distinct regions: epidermis (epithelial layer - thick, keratinized stratified squamous epithelium) and dermis (CT) 1. Epidermal cells (4 types): (1) keratinocytes: What is the main function of keratinocytes? What is the lifespan of a keratinocyte? J. C arnegie, UofO http://www.nanogenshop.com/producten/onescalp.html
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(2) melanocytes : produce melanin; deepest layer of epidermis; numerous branching processes for melanin transfer to adjacent cells ( function?? ) What is the role of melanocytes in contributing to skins of different colour/tanning ability? (3) Langerhans cells : = epidermal dendritic cells (star-shaped); migrate to epidermis from bone marrow; macrophages  activate immune system (4) Merkel cells : = tactile cells; at epidermis/dermis boundary; have disc-like sensory nerve ending - touch receptors Fig. 5.2 (7th edition) J. C arnegie, UofO
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(v) stratum corneum: thickest on palm of hand & soles of feet; dead cells filled with keratin fibrils; strong, protective, waterproof (iv) stratum lucidum: no nourishment from capillaries; few rows of clear, flat, dead keratinocytes; keratohyaline granules parallel (iv) stratum granulosum: cells flatten, nuclei/organelles begin to disintegrate; accumulate keratohyaline & lamellated granules (ii) stratum spinosum: web of keratin filaments attached to desmosomes; name reflects ???; melanin, Langerhans cells (iii) stratum basale:
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This note was uploaded on 02/08/2012 for the course ANP 1105 taught by Professor Carnegie during the Fall '08 term at University of Ottawa.

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1106Topic2 2011 - Topic 2: THE INTEGUMENTARY SYSTEM Chapter...

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