notesterm1 - *Most* foreign antigens, if injected in their...

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**Most*** foreign antigens, if injected in their ***pure form***, will not induce an immune response. This is because our immune system needs 2 "signals" to respond to an antigen: 1) A foreign antigen which can be recognized by a lymphocyte that has survived central tolerance 2) An indication that the antigen is associated with something dangerous (i.e. a DAMP or PAMP). Note that the DAMP/PAMPs is usually "seen" by the APC, not the T/B cell. Eosinophils main "job" is anti-parasite immunity, and allergies are a product of activating these cells in response to an inappropriate antigen (i.e. pollen). The roles of basophils are not well understood. They are very similar in their cellular contents to eosinophils, and as such it is assumed they are involved in similar immune responses (i.e. parasite and allergy). However, that is an assumption based on minimal data - in reality, the role of basophils has been minimally explored, and they may have a unique role different than that of eosinophils.
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This note was uploaded on 02/08/2012 for the course PATHOLOGY 3245 taught by Professor X during the Spring '11 term at UWO.

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notesterm1 - *Most* foreign antigens, if injected in their...

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