BIOS E-1a Introduction to Molecular and Cellular Biology f11

BIOS E-1a Introduction to Molecular and Cellular Biology...

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Unformatted text preview: Instructor: Office Hours: Head TF: Course Email: Meeting Times: Description: Prerequisites: Course Website: Textbook: Grading: BIOS E ­1a: Introduction to Molecular and Cellular Biology Fall 2011 William J. Anderson, Ph.D. Department of Stem Cell and Regenerative Biology Harvard University Bauer Laboratory, Room 204 7 Divinity Ave. Cambridge, MA 02138 Monday, Wednesday 6:00 ­7:00pm Tara Mann, Ph.D. BIOS.E1ab@gmail.com Monday, Wednesday 7:35 ­9:35pm Science Center B BIOS E ­1a and BIOS E ­1b provide a one ­year introduction to modern biology that fulfills medical school requirements. During some weeks, students attend a laboratory instead of a lecture. BIOS E ­1a focuses on the general principles of cellular biology. Topics include the structure of cells, the distinction between prokaryotic and eukaryotic systems, enzymes and cellular metabolism, and the general principles of modern genetics. High school mathematics, chemistry, and biology; although CHEM E ­1a and E ­1b, or their equivalents, are not required, they are strongly recommended. http://isites.harvard.edu/k81326 Hillis, Sadava, Heller, and Price Principles of Life (2012) ISBN# 978 ­1 ­4292 ­5721 ­3 Exam #1 Exam #2 Laboratory Final Exam 25% 25% 25% 25% Date 8/29 8/31 9/5 9/7 9/12 9/14 9/19 9/21 9/26 9/28 10/3 10/5 10/10 10/12 10/17 10/19 10/24 10/26 10/31 11/2 Title Introduction / Atoms, Molecules, and Chemical Bonds Reading: Chapters 1, 2 Molecules of Life Reading: Chapter 3 NO MEETING – Labor Day Enzymes Reading: Chapter 3 LAB  ­ Enzymes LAB  ­ Enzymes Cell Theory Reading: Chapter 4 Membrane Structure and Function Reading: Chapter 5 Cellular Metabolism Reading: Chapters 6 Photosynthesis Reading: Chapter 6 LAB – Photosynthesis LAB – Photosynthesis NO MEETING – Columbus Day EXAM #1 (covers material from 8/29 to 9/28) Chromosome Theory Reading: Chapter 7 Mendelian Genetics Reading: Chapter 8 LAB – Mitosis and Meiosis / PCR LAB – Mitosis and Meiosis / PCR Chromosome Mapping / DNA Reading: Chapter 9 Transcription and Translation Reading: Chapter 10 11/7 Prokaryotic Gene Regulation Reading: Chapter 11 11/9 Eukaryotic Gene Regulation Reading: Chapter 11 11/14 LAB – lac operon / PCR 11/16 LAB – lac operon / PCR 11/21 DNA and the Biology of Cancer Reading: Chapters 7, 8, 9 11/23 NO MEETING – Thanksgiving Recess 11/28 Genetic Engineering Reading: Chapter 13 11/30 EXAM #2 (covers material from 10/17 to 11/21) 12/5 Human Genetics Reading: Chapter 14 12/7 LAB – Review (all sections) 12/12 LAB – Practical (all sections) 12/14 FINAL EXAM (cumulative) Noteworthy Dates: Sunday, 9/11 Deadline for course and credit status changes Deadline to drop the course with 100% tuition refund Sunday, 9/18 Deadline to drop the course with 50% tuition refund Sunday, 11/27 Deadline to withdraw with WD/WN grade on record Exams: Unless otherwise noted, exam material will consist of topics covered in lecture and the corresponding readings in the text. All lecture material is fair game for exams. Students are responsible for material from the readings even if not explicitly discussed in lecture, unless told to ignore by the Instructor or Head TF. Of note, material presented in the lectures will be drawn from sources other than the text. There will be NO MAKEUP EXAMS except for extenuating circumstances. Laboratory: Sectioning: Students will be asked to complete an online sectioning poll to query which lab day they prefer. Preferences are considered but not guaranteed. Lab Manual: Laboratory protocols will be available to download from the course website prior to lab. Grading: The laboratory grade consists of attendance in laboratory sessions, good laboratory practice (cleaning up, following safety rules, etc.), and laboratory reports. The breakdown is as follows: Lab Date / Data Collection Assignment Due Date Points 9/12 Enzymes Lab 9/21 20 points 9/14 Enzymes Lab 9/21 10/3 Photosynthesis 10/17 20 points 10/5 Photosynthesis 10/17 10/24 Mitosis and Meiosis In Lab Quiz 20 points 10/26 Mitosis and Meiosis In Lab Quiz 11/14 lac Operon 11/21 20 points 11/16 lac Operon 11/21 11/14 Run PCR Gel 11/28 20 points 11/16 Run PCR Gel 11/28 12/12 Lab Practical 100 points Total 200 points Late assignments will be docked 10% for each week late up to two weeks. After 2 weeks, no credit will be given. It is still a good idea to turn in late work to the TA in order to get comments and correction that will help in studying for the lab practical. NOTE: There are no make ­up laboratory sessions. If a student foresees an absence for a particular week, they should contact their TA well in advance to see what, if any, arrangements can be made. The lab practical is a timed, cumulative test covering all lab exercises this semester. The format is different from a standard written exam. Questions will be set up as stations, with exhibits requiring students to use information, skills, and reasoning learned in each lab. Assignments: Assignments will be submitted using the course website under the folder “Assignment Drop Box”. Files will be uploaded by students to their corresponding TA folder. All assignments must be uploaded by 5pm on the assignment due date to avoid late penalties. Safety: Absolutely no food or drink is allowed in the lab, no open toed shoes, and no contact lenses. Warnings will be given if special care is needed with any of the reagents. Students should pay attention to recommendations for using gloves or eye protection. People with long hair should tie it up or wear a hat to control it while in lab, especially if Bunsen Burners are in use. Students should be familiar with the positions of the eye wash station, fire alarm, power kill switch, fire extinguisher and blanket, and first aid kit. Plagiarism and Cheating: Even though students will be working with lab partners, all written work must be the student’s own. Students may discuss work with others, but should be sure to write everything in their own words. Students also may not copy writings from textbooks, journals or the lab protocols without proper citations. Plagiarism is a very serious offense. Quizzes and tests will be taken individually, and students will not be allowed to refer to any books or notes during their administration. Students may not look at other students’ papers during quizzes and tests. Calculators may be allowed for solving mathematical problems only. Anyone caught plagiarizing or cheating during lab will be disciplined, and may be sent before the Administration Board or expelled from the course. ...
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