Lecture 5 – Protein Function

Lecture 5 - (topic4 . body.:enzyme,structure,transport(,motorfunction(movement,storage,signal receptor(detects

Info iconThis preview shows pages 1–2. Sign up to view the full content.

View Full Document Right Arrow Icon
Lecture 5 – Protein Function (topic 4)   Proteins serve many purposes. There are several hundred thousand of them in our  body. Their many purposes include the following: enzyme, structure, transport  (carries small molecules or ions), motor function (movement), storage, signal,  receptor (detects signals and transmits them to the cell), gene regulation etc.  Protein surfaces have a huge variety of shapes and charge distribution. This is due  to the variety of amino acid side chains. Many arrangements are made out of  secondary and tertiary structure (folding patterns).  Proteins can also be flexible. They can undergo structural changes called  conformational changes. This is the driving force behind motor proteins, control  of enzyme activity and sensory function of receptors.  Many proteins contain sites to which ligands specifically bind and form a complex  with the protein. Ligands are molecules that form this complex and the binding  occurs by multiple weak forces. This leads to extreme specificity  The binding (weak forces) occur between the side chains of the complex (protein). Kd (dissociation constant) is a measure of the strength or affinity of an interaction  of ligand to protein.  For protein (P) and binding ligand (L): o         NOTE: this is OPPOSITE to Ka and Kb values  for acids and bases.  High affinity = tight bonding = small Kd Protein complexes contain multiple proteins. Complexes contain many proteins. 
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 2
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 02/09/2012 for the course SCIENCE 2820 taught by Professor Brandl during the Spring '11 term at UWO.

Page1 / 4

Lecture 5 - (topic4 . body.:enzyme,structure,transport(,motorfunction(movement,storage,signal receptor(detects

This preview shows document pages 1 - 2. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online