Lecture 10 – Membrane Proteins

Lecture 10 – Membrane Proteins - group...

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Topic 8 – Membrane Proteins (Lecture 10) The composition of a membrane (by mass) is the following: about 50% lipids,  about 50% proteins and about 1-2% carbohydrates.  The fluid mosaic model describes how proteins are free to diffuse laterally within  the bilayer unless movement is restricted by cellular components.  Membrane proteins  have the following  functions:  transporters,  anchors, receptors and  enzymes.  There are 4 types of membrane proteins: transmembrane,  monolayer-associated, lipid linked and protein attached. The last is a peripheral  membrane protein. Transmembrane proteins are exposed to both sides and are always alpha helical in  structure. This maximizes the hydrogen bonding between the polar backbone 
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Unformatted text preview: group minimizing the interaction between the hydrophobic interior. There are about 20 amino acids that’s span the bilayer. This is an integral membrane protein. • Monoassociated proteins only span one side of the bilayer. The hydrophobic part is embedded into the layer. • Lipid linked are proteins that are covalently bonded to lipids in the membrane. It is usually covalently bonded to cysteine. • Because protein attached are peripheral membrane proteins, it is easier to study because you just need to break the interaction between the transmembrane protein and the attached protein....
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