SDS-outline+chapter+5

SDS-outline+chapter+5 - Chapter 5 Notes LIQUID SOLUBILITY...

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Chapter 5 Notes LIQUID SOLUBILITY OF THE DRUG IS DETERMINED SIMILARLY TO SEEING SALAD OIL MIX WITH WATER ONE LOOKS TO SEE HOW MUCH FLOATS ALOP. THERE ARE THREE MAIN ROUTES FOR TAKING DRUGS. ORAL IS MOST COMMON BUT IS IS ALSO THE MOST DIFFICULT FOR ENTERING THE BLOODSTREAM AS THEY MUST GO THROUGH THE STOMACH, INJECTION THIS IS ADMINISTERED THROUGH A HYPODERMIC SYRINGE. THOUGH THIS IS QUICK AND EFFECTIVE CONTINUOUSLY BREAKING THE WALL WITH THE IV COLLAPSES THE WALLS EVENTUALY AND CAUSES THE USER TO NEED TO FIND ANOTHER ROUTE. THIS ALSO GIVES CHANCE FOR HIV AIDS IN THE CASE OF USED NEEDLES. INTRAMUSCULAR INJECTION IS MORE RAPID AS THE MUSCLES HAVE A BETTER BLOOD SUPPLY THAN THE LAYERS OF SKIN INVOLVED WITH SUBCUTANEOUS INJECTIONS. INHALATION THIS METHOD IS USED FOR SMOKING. IT IS RAPID AS THE CAPILLARY WALLS IN THE LUNGS ARE EASILY ACCESIBLE. THE FINAL ROUTE IS ABSORPTION THROUGH SKIN THOUGH THIS IS STEADY AND MAINTAINS ITSELF OVER A LONG PERIOD OF TIME IT IS NOT AS POPULAR AS THE OTHER METHODS. http://www.google.com/imgres? t.org/biopharmaceutics.html&docid=psHaLQarxfm-vM&w=558&h=243&ei=KpFlTv- http://t2.gstatic.com/images? q=tbn:ANd9GcTnicXsvO5H7FXaTjfID2W2A_1tyPM_DIfoyk5qzs88FzTy0Wmi BECAUSE DIFFERENT DRUGS HAVE DIFFERENT AFFINITIES FOR THE PLASMA PROTEINS ONE MIGHT EXPECT THAT DRUGS WITH HIGH AFFINITY WOULD DISPLACE DRUGS WITH WEAK PROTEIN BONDS, AND THEY DO THIS FACT IS IMPORTANT BECAUSE IT FORMS THE BASIS FOR ONE KIND OF DRUG INTERACTION. BBB KEEPS SOME COMPOUNDS IN THE BLOOD AWAY FROM BRAIN CEREBRAL TRAUMA CAN DISRUPT THE BARRIER BOFORE A DRUG HAS NO EFFECT ONE OF TWO THINGS HAPPEN IT IS EITHER EXCRETED FROM THE HOST OR BODY . MOST OF THE TIME THIS MEANS IN THE URINE. THE OTHER POSSIBILITY IS A CHEMICAL CHANGED SO THAT THE EFFECT IS DIFFERENT. %3A%2F%2Fwww.flyfishingdevon.co.uk%2Fsalmon %20OF%20TOLERANCE%20AND%20WITHDRAWAL
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%20SYMPToms&ei=uZllTuijEsTJ0AGbpuW6Cg&usg=AFQjCNE3ZeyKohKK5oQuuC- b3dDenGNeQw&cad=rja
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Drug Effects: Nonspecific effects : derived from user’s personal background, anything except the chemical affect of drug (sometimes called placebo effect) -can be produced by an inactive drug
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SDS-outline+chapter+5 - Chapter 5 Notes LIQUID SOLUBILITY...

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