BMB401-506 2007 Exam 4 F0

BMB401-506 2007 Exam 4 F0 - I, (Name) _ have neither...

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I, (Name) _________________________________________ have neither received nor given help BMB 401/506-Fall 2007 Fourth Examination November 29, 2007 During the exam you should not be in possession of a beeper, cellular phone or any other electronics. Please place all electronic devices (turn them off!!!), books and papers in your book bag and place the bag against the wall of the room. THESE ARE STANDARD SINGLE ANSWER MULTIPLE CHOICE QUESTIONS. THE POSSIBLE ANSWERS ARE LABELED A,B,C,D AND E. SELECT THE SINGLE BEST ANSWER AND MARK THE APPROPRIATE CIRCLE ON THE SCANTRON ANSWER SHEET. BUBBLE IN YOUR NAME AND ID# (C# ONLY PLEASE) . There are 35 questions. You will receive full credit for 34 correct answers. 1. Simple fatty acids ( e.g. butyrate) are currently tested in clinical trials for the treatment of beta thalassemia and sickle cell disease. These drugs work by A. inhibiting beta-globin polymerization B. specifically blocking beta-globin gene expression C. specifically activating fetal (gamma-) globin gene expression D. increasing heterochromatin & nonspecifically blocking beta-globin gene expression E. decreasing heterochromatin & nonspecifically activating fetal (gamma-) globin gene expression 2. Mutations always A. alter protein sequences B. alter RNA sequences C. alter DNA sequences D. have deleterious consequences E. Two of the above 3. Which of the following properties are not shared by E. coli RNA polymerase and DNA polymerase III? A. DNA template B. Direction of synthesis 5’ 3’ C. Primer required D. 3’-OH makes nucleophilic attack on substrate E. Pyrophosphate product 4. Which of the following DNA sequences is a palindrome? A. 5’– AGCGCCGCGT –3’ B. 5’– GCATATATGC –3’ C. 5’– CGAGTACACG –3’ D. 5’– CGATCCTAGC –3’ E. 5’– CGATACGATA –3’ 5. The sequence 5’…ATGCCCTTTGGGTGAAAA…3’ encodes a tetrapeptide. Nitrous acid treatment was used to introduce a single nucleotide substitution in the stop codon. Which of the following peptide sequences could result from this treatment?: A. Met-Pro-Phe-Gly-Trp-Lys B. Met-Pro-Phe-Gly C. Met-Pro-Phe-Gly-Arg-Lys D. All of the above E. None of the above 6. Identify the compound at right: A. Deoxyinosine B. Deoxyhypoxanthine C. Deoxyuridine D. Deoxycytidine E. Deoxythymidine 7. The compound illustrated in the previous question is A. a purine B. a nucleotide C. a nucleoside D. a base E. None of the above 8. Deletion of a transcription element yields: A. Mutant protein B. Mutant mRNA C. Mutant hnRNA D. Transcription defects E. Termination defects 9. How do transcription activator proteins locate their enhancer elements? A.
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BMB401-506 2007 Exam 4 F0 - I, (Name) _ have neither...

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