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Unformatted text preview: I, (Name) _________________________________________ have neither received nor given help BMB 401/506-Fall 2004 Third Examination November 9, 2004 KEY During the exam you should not be in possession of a beeper or a cellular phone. Please place your beeper and/or cellular phone in your book bag (after you turn it off!!!) and place the bag against the wall of the room. THESE ARE STANDARD SINGLE ANSWER MULTIPLE CHOICE QUESTIONS. THE POSSIBLE ANSWERS ARE LABELED A,B,C,D AND E. SELECT THE SINGLE BEST ANSWER AND MARK THE APPROPRIATE CIRCLE ON THE SCANTRON ANSWER SHEET. BUBBLE IN YOUR NAME AND ID# (C# ONLY PLEASE) . There are 45 questions. You will receive full credit for 43 correct answers. 1. N-9 is derived from A. Asparagine B. Formyl-tetrahydrofolate C. Glutamine D. Glycine E. Ribose 2. Inhibition of carnitine palmitoyl transferase 1 will have the following effect: A. Increased ATP production B. Decreased ATP production via glycolysis C. ATP production will be unaffected D. Decreased ATP production via -oxidation 3. Sterol regulatory element binding protein (SREBP) is a transcription factor regulating expression of many genes encoding lipogenic enzymes including hydroxymethylglutaryl CoA (HMG-CoA) reductase gene. How does low levels of cholesterol result in the transcriptional activation of the HMG-CoA reductase gene? A. An amino-terminal fragment of endoplasmic membrane-anchored SREBP is released by proteolytic cleavage B. The released peptide enters nucleus where it binds to the sterol regulatory element (SRE) of HMG-CoA reductase gene C. Binding of the peptide to SRE enhances the rate of transcription of the HMG-CoA reductase gene D. All of the above in the order stated E. All of the above but in a different order 4. The reaction catalyzed by s-adenosylmethionine synthase results in the formation of s-adenosylmethionine and: A. ADP and orthophosphate B. AMP and pyrophosphate C. AMP and orthophosphate D. Pyrophosphate and orthophosphate 5. Which of the following pair of amino acids is phosphorylated by protein kinase C? A. Tyr/Ser B. Tyr/Thr C. Ser/Thr D. His/Tyr 6. Which of the following pair of vitamins participate in the enzymatic conversion of propionate to succinate? A. Folate/Biotin B. Biotin/Thiamine pyrophosphate (TPP) C. Folic acid/Vitamin B 12 D. Biotin/Vitamin B 12 E. TPP/Vitamin B 12 7. Which ONE of the following tissues is unable to use glycerol (for glycolysis and/or esterification of fatty acids) obtained from the hydrolysis of triglycerides by lipases? A. Liver B. Heart C. Adipose tissue D. Skeletal muscle BMB 401 2004 Department of Biochemistry & Molecular Biology, University of Miami, reproduction prohibited. Page 1 of 4 I, (Name) _________________________________________ have neither received nor given help 8. Inactivation of acetyl CoA carboxylase by the AMP- activated protein kinase: A. Will result in an increase in the rate of -oxidation of fatty acids B. Will result in a decrease in the rate of -oxidation of fatty acids...
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