Ch03_Molecular_Biology_Primer

Ch03_Molecular_Biology_Primer - www.bioalgorithms.info An...

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Unformatted text preview: www.bioalgorithms.info An Introduction to Bioinformatics Algorithms Molecular Biology Primer Angela Brooks, Raymond Brown, Calvin Chen, Mike Daly, Hoa Dinh, Erinn Hama, Robert Hinman, Julio Ng, Michael Sneddon, Hoa Troung, Jerry Wang, Che Fung Yung An Introduction to Bioinformatics Algorithms www.bioalgorithms.info Outline: 0. History: Major Events in Molecular Biology 1. What Is Life Made Of? 2. What Is Genetic Material? 3. What Do Genes Do? 4. What Molecule Code For Genes? 5. What Is the Structure Of DNA? 6. What Carries Information between DNA and Proteins 7. How are Proteins Made? An Introduction to Bioinformatics Algorithms www.bioalgorithms.info Outline Cont. 8. How Can We Analyze DNA 1. Copying DNA 2. Cutting and Pasting DNA 3. Measuring DNA Length 4. Probing DNA 9. How Do Individuals of a Species Differ 10. How Do Different Species Differ 1. Molecular Evolution 2. Comparative Genomics 3. Genome Rearrangement 11. Why Bioinformatics? An Introduction to Bioinformatics Algorithms www.bioalgorithms.info How Molecular Biology came about? Microscopic biology began in 1665 Robert Hooke (1635-1703) discovered organisms are made up of cells Matthias Schleiden (1804- 1881) and Theodor Schwann (1810-1882) further expanded the study of cells in 1830s Robert Hooke Theodor Schwann Matthias Schleiden An Introduction to Bioinformatics Algorithms www.bioalgorithms.info Major events in the his tory of Molecular Biology 1800 - 1870 1865 Gregor Mendel discover the basic rules of heredity of garden pea. An individual organism has two alternative heredity units for a given trait ( dominant trait v.s. recessive trait ) 1869 Johann Friedrich Miescher discovered DNA and named it nuclein. Mendel: The Father of Genetics Johann Miescher An Introduction to Bioinformatics Algorithms www.bioalgorithms.info Major events in the his tory of Molecular Biology 1880 - 1900 1881 Edward Zacharias showed chromosomes are composed of nuclein. 1899 Richard Altmann renamed nuclein to nucleic acid. By 1900 , chemical structures of all 20 amino acids had been identified An Introduction to Bioinformatics Algorithms www.bioalgorithms.info Major events in the his tory of Molecular Biology 1900-1911 1902- Emil Hermann Fischer wins Nobel prize: showed amino acids are linked and form proteins Postulated: protein properties are defined by amino acid composition and arrangement, which we nowadays know as fact 1911 Thomas Hunt Morgan discovers genes on chromosomes are the discrete units of heredity 1911 Pheobus Aaron Theodore Lerene discovers RNA Emil Fischer Thomas Morgan An Introduction to Bioinformatics Algorithms www.bioalgorithms.info Major events in the his tory of Molecular Biology 1940 - 1950 1941 George Beadle and Edward Tatum identify that genes make proteins 1950 Edwin Chargaff find Cytosine complements Guanine and Adenine complements Thymine George Beadle Edward Tatum Edwin Chargaff An Introduction to Bioinformatics Algorithms...
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This note was uploaded on 02/10/2012 for the course CSE 5615 taught by Professor Mitra during the Fall '11 term at FIT.

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Ch03_Molecular_Biology_Primer - www.bioalgorithms.info An...

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