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Week_11_-_Methods_in_neurotoxicology - Week 11 Methods in...

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Week 11 - Methods in neurotoxicology A large number of in vivo and in vitro tests exist for studying neurotoxicity. A few representative approaches are discussed below. In Vivo Neurotoxicology Tests A large number of in vivo neurotoxicity tests are behavioral if an animal’s behavior changes significantly following exposure to a suspected neurotoxicant, it may be an indication that the compound is neurotoxic. Observed behaviors can include the acquisition or loss of learning, motor coordination, or memory. For example, one common memory test involves using a radial arm maze, which has eight arms extending off a central area. Treats are placed at the end of one arm, and small animals (usually mice or rats) are trained to remember where the treats are located, based on visual cues outside the maze. If a neurotoxicant affects memory, then loss of the ability to successfully find the treat will become apparent.
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  • Summer '11
  • hess
  • ion channel function, Neurotoxicology, Vivo Neurotoxicology Tests, vivo neurotoxicity tests, Vitro Neurotoxicology Tests

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