Week_11_-_Methods_in_neurotoxicology

Week_11_-_Methods_in_neurotoxicology - Week 11 - Methods in...

Info iconThis preview shows page 1. Sign up to view the full content.

View Full Document Right Arrow Icon
Week 11 - Methods in neurotoxicology A large number of in vivo and in vitro tests exist for studying neurotoxicity. A few representative approaches are discussed below. In Vivo Neurotoxicology Tests A large number of in vivo neurotoxicity tests are behavioral – if an animal’s behavior changes significantly following exposure to a suspected neurotoxicant, it may be an indication that the compound is neurotoxic. Observed behaviors can include the acquisition or loss of learning, motor coordination, or memory. For example, one common memory test involves using a radial arm maze, which has eight arms extending off a central area. Treats are placed at the end of one arm, and small animals (usually mice or rats) are trained to remember where the treats are located, based on visual cues outside the maze. If a neurotoxicant affects memory, then loss of the ability to successfully find the treat will become apparent. On a physiological level, researchers can study the electrical activity of neurons using an
Background image of page 1
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 02/10/2012 for the course PHY 495 taught by Professor Hess during the Summer '11 term at Alabama.

Ask a homework question - tutors are online