Week_4_Learning_Objectives_and_Assignmen

Week_4_Learning_Objectives_and_Assignmen - Understand the...

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Learning objectives: Understand the basic structure and function of DNA and chromosomes Understand the relationship between DNA, RNA and protein (the 'central dogma' of molecular biology) Understand the various types of mutations and chromosomal alterations Understand the difference between recessive and dominant mutations Understand the differences between benign and malignant tumors Understand and be able to describe the various stages of carcinogenesis and the essential alterations in cell physiology that are required for malignant cell growth Understand and be able to explain the roles of proto-oncogenes, oncogenes and tumor suppressor genes in carcinogenesis
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Unformatted text preview: Understand the following terms: complete carcinogen, ultimate carcinogen, direct-acting carcinogen and indirect-acting carcinogen Understand the roles that xenobiotics may play in carcinogenesis Understand the concept of epigenetic carcinogenesis Required reading: Casarett and Doull's: Chapters 8 & 9 (pages 109 - 134) Hanahan and Weinberg (2000). The Hallmarks of Cancer. Cell . Vol 100: 57-70. Klaunig et al. (2000). Epigenetic mechanisms of chemical carcinogenesis. Hum Exp Toxicol. Vol 19: 543-555. Watters (2006). DNA is Not Destiny. Discover Magazine. Assignments: 1) Review Week 4 lecture content 2) Homework #2 due 6/12/2011 (submission quiz is available in Week 4 folder)...
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