Chapter 9 Cell Communication 2011 (1)

Chapter 9 Cell Communication 2011 (1) - Three Classes of...

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Chapter 9 Cell Communication Learning Objectives 1. To understand the importance of communication between cells 2. To understand the four types of cell signaling. 3. To understand the nature of ligands and how they operate 4. To understand the differences between intracellular and membrane bound receptors 5. To understand how steroid receptors operate 6. To understand G protein coupled receptors and the role of second messengers.
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Four Types of Cell Signaling 1. Direct Contact 2. Paracrine Signaling 3. Endocrine Signaling 4. Synaptic Signaling
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Overview of Signaling Between Cells Ligands Receptors
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Role of Phosphorylation in Protein Function 1. Phosphorylated proteins are either active or inactive depending upon the specific protein 2. Phosphorylated or Dephosphorylated proteins are often involved in signal transduction pathways.
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Unformatted text preview: Three Classes of Membrane Receptors: A. Chemically Gated Ion Channels B. Enzymatic Receptors C. G Protein Coupled Receptors Examples of Membrane Receptors Chemically gated ion channels Enzymatic receptors G Protein Coupled Receptor Intracellular Receptors Example: Steroid Hormone Receptors Signal Transduction Through G Protein Coupled Receptors 2 Part Process: A. Hormone (first messenger) activates the G protein B. G Protein activates the effector proteins either Adenylyl cyclase or phosholipase C C. Adenylyl cyclase produces cyclic AMP which is a second messenger Hormone activates the receptor and the G protein Effector Protein (Adenylyl Cyclase) Produces the Second Messenger Cyclic AMP...
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This note was uploaded on 02/12/2012 for the course BIOL 104 taught by Professor Dr.nevinaspinwall during the Fall '11 term at MO St. Louis.

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Chapter 9 Cell Communication 2011 (1) - Three Classes of...

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