Unit11 - Unit 11 1 UNIT 11 PART A: PYRUVATE DEHYDROGENASE...

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Unit 11 1 U NIT 11 P ART A: P YRUVATE D EHYDROGENASE AND THE TCA C YCLE P ART B: T HE P ENTOSE P HOSPHATE P ATHWAY P ART A: T HE P YRUVATE D EHYDROGENASE C OMPLEX AND THE TCA C YCLE In Unit 10, you learned that glucose is converted to pyruvate by glycolysis in the cytosol. Pyruvate is transported through the mitochondrial inner membrane by a pyruvate transporter. An activated two carbon compound, acetyl CoA, is generated from pyruvate in the mitochondrion. Acetyl CoA then enters into the TCA cycle where large amounts of reducing power (energy) are generated in the form of NADH and FADH 2 . Assignment: Nelson & Cox, pp. 601 - 623. Since time does not permit study of the pyruvate dehydrogenase complex in as much detail as Nelson & Cox supplies, please read through the assignment and then go back to answer the objectives one by one. You are not required to learn the detailed mechanisms, but we want you to understand the role of each of the coenzymes involved. 1. Oxidative decarboxylation of pyruvate to acetyl CoA (pp. 602 - 606) a. What is the name of the enzyme complex that forms acetyl CoA from pyruvate? (Fig. 16-2, p. 602) b. Write the net reaction catalyzed by the pyruvate dehydrogenase complex. (Fig. 16-2, p. 602)
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Unit 11 2 c. How many coenzymes are involved in the conversion of pyruvate to acetyl CoA? Name them (p. 603). d. How many enzymes are involved in the conversion of pyruvate to acetyl CoA? e. Discuss "substrate channeling" (p. 605-6). What is the advantage of having these enzymes organized into a complex? f. Which coenzyme binds pyruvate and accomplishes the decarboxylation (See Fig. 14-13, p. 541, for a detailed structure)? g.
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Unit11 - Unit 11 1 UNIT 11 PART A: PYRUVATE DEHYDROGENASE...

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