Prelim 2 Fall07

Prelim 2 Fall07 - BioBM 330 2nd Prelim Name 30 October 2007...

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BioBM 330 Name ____________________________ 2nd Prelim 30 October, 2007 Please do not lift this sheet until the signal is given! Please be certain that your exam contains a total of 11 pages! Please write your name on EACH page. We urge you not to get bogged down on any one question. If you do not see the point fairly quickly, go on to the other questions and come back if time permits. You may have two hours for the whole exam. 1. _________ (5) 11. _________ (8) 2. _________ (5) 12. _________ (7) 3. _________ (7) 13. _________ (2) 4. _________ (2) 14. _________ (7) 5. _________ (3) 15. _________ (3) 6. _________ (3) 16. _________ (2) 7. _________ (2) 17. _________ (6) 8. _________ (9) 18. _________ (3) 9. _________ (11) 19. _________ (4) 10._________ (3) 20. _________ (2) Total _________________ (94) First Position (5' end) Second Position Third Position (3' end) U C A G Phe U U C C A A G G U C A G U C A G U C A G Phe Leu Leu Leu Leu Leu Leu Ile Met Ile Ile Val Val Val Val Ser Ser Ser Ser Pro Pro Pro Pro Thr Thr Thr Thr Ala Ala Ala Ala Tyr Stop Tyr Stop His Gln Gln His Asn Lys Asn Lys Asp Glu Asp Glu Cys Stop Trp Cys Arg Arg Arg Arg Ser Ser Arg Arg Gly Gly Gly Gly
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BioBM330 2nd prelim 10/30/07 Name: ___________________________2 1. a. (1 point) Which one of "Chargaff's rules" was helpful to Watson and Crick for building their model of DNA structure? b. (1 point) What other key observation was used to build the model? c. (3 points) List three important features of the model. 2. a. (1 point) Name or briefly describe the spontaneous chemical reaction in DNA that causes the change of a G/C base pair to an A/T base pair following replication (if the error is not corrected). b. (1 point) What feature of DNA makes it possible for cells to detect and repair instances of the reaction described in part "a" above? c. (3 points) List the four steps required to correct the above error. For two of the steps, name the enzyme involved. 1) 2) 3) 4)
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BioBM330 2nd prelim 10/30/07 Name: ___________________________3 3. a. (2 points) Using the replication bubble below, draw in and label the newly synthesized leading and lagging strands. Use a squiggled line to represent primers. Label the 5' and 3' ends of the strands and include arrows to indicate the direction of replication. 5'
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This note was uploaded on 04/06/2008 for the course BIOBM 3300 taught by Professor Blankenshi during the Fall '08 term at Cornell.

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Prelim 2 Fall07 - BioBM 330 2nd Prelim Name 30 October 2007...

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