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hw5 - STATISTICS 500 Fall 2009 Homework 5 handed out...

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STATISTICS 500 – Fall 2009 Homework 5 - handed out Saturday, 26 Sept 2009 DUE DATE: on campus Friday, 2 Oct 2009, in lecture (11 am) or by e-mailto Chuanlong, [email protected], no later than noon. off campus Monday, 5 Oct 2009, by 4 pm to Nicole Rembert, email: [email protected] or FAX: 515-294-4040 (please include cover page with Stat 500 / Nicole Rembert). Coming up: on campus off campus HW 5 due Oct 2 Oct 5 Midterm 1 Oct 8, 7 - 9 pm by 5 pm Oct 16 No HW assignment Oct 9 Oct 12 HW 6 due Oct 16 Oct 19 1. Diagnostics — Let’s reconsider the diet and longevity study described last week. The data are in dietlong.txt on the class web site. (a) Is the assumption of independence reasonable? Explain why or why not. (b) Is the assumption of equal variance reasonable? Explain why or why not. Note: Choose and report your favorite assessment of equal variance. You do not need to use everything we’ve talked about. (c) Is the assumption of normality reasonable? Explain why or why not. Again, choose and report one method. You do not need to do all. 2. The data in fdrA.txt and fdrB.txt are made-up to represent typical results from a genome-wide study of associ- ation between markers on the genome and a particular biological outcome. These studies test the associateion between a very large number of markers, considered individually, and the outcome. Hence, they generate very large numbers of p-values. The only difference between these data and a typical study is that I am only giving you p-values for 100 tests. Hint: there is no SAS procedure to calculate the adjusted p-value. You can either use proc sort (see tomato.sas from week 2 lab) or do all the calculations in excel or other language. Remember, you don’t have to continue once the sorted (original) p-value is > 0.05.
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