PrinciplesDiseasePt1_OLS

PrinciplesDiseasePt1_OLS - Principles of Disease Part 1...

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Principles of Disease Part 1: Virulence Factors Involved in Infectious Diseases Disease Any deviation from a state of health Infectious Disease Disruption of a tissue or organ caused by microbes or their products Infection Entry, establishment, and multiplication of microbes within a host Pathogenicity Ability of microbes to cause disease Virulence Level of pathogenicity (how bad is the bug?) Virulence Factor Any characteristic that assists a microbe in causing disease Bacterial Virulence Factors 1. Bacterial virulence factors are molecules or cell structures that Allow attachment to host cells and/or Allow immune system evasion and/or Damage the host organism either directly or indirectly 2. The virulence of a particular bacterial species depends on its particular arsenal or virulence factors Bacterial Virulence Factors for Attachment to Host Cells 1. Bacterial surface molecules (adhesion molecules, capsules, fimbriae) bind specifically to complementary receptors on host cell surfaces 1
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PrinciplesDiseasePt1_OLS - Principles of Disease Part 1...

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