lecture notes-bioreactor analysis and operation-5-scale-up-down-lecture notes

Lecture notes-bioreactor analysis and operation-5-scale-up-down-lecture notes

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Scale-up/down Scale-up: For the optimum design of a product-scale fermentation system (prototype ), the data on a small scale (model ) must be translated to the large scale. The fundamental requirement for scale up is that the model and the prototype should be similar to each other. Two kinds of conditions must be satisfied to ensure similarity between the model and the prototype. - Geometric similarity of the physical boundaries - Dynamic similarity of the flow fields
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Scale-up/down Scale-up: - Geometric similarity of the physical boundaries: - same type of reactor - all linear dimensions of the model must be related to the corresponding dimensions of the prototype by a constant scale-up factor. i.e. Keep the ratio of the height H to diameter D t (tank) same in the model and prototype. Normally H/D t is 2~3. ... = = m p m p D D H H Scale-up factor: Ratio of surface to volume decreases during scale-up.
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Example: Scale-up 2 litre cylindrical tank (Vm) is scaled up to 2000 litre (Vp) fermenter by geometrical
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Lecture notes-bioreactor analysis and operation-5-scale-up-down-lecture notes

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