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Unformatted text preview: • Modified batch and continuous reactors Multistage chemostat reactor ) 1 ( ) , ( , ) 1 (= == n X n X n D n X net n S x X n x r n X n X n D n X net μ ) 1 ( 1 ) , ( , ) 1 ( ) , ( , /== n S n S n D Y n S x X n s r n P n P n D n S x X n p r S X Summary of Bioreactor Design and Operation • Scaleup/down Geometric similarity Dynamics similarity • Sterilization Probability of unsuccessful sterilization 1 P (t)= 1[1ek d t ] N 0  Deactivation of components in media C=C ekdt • Immobilized cell systems Advantages and disadvantages • Operation consideration agitation and aeration, determination of volumetric mass transfer coefficient k L a, heat removal, foam, etc. Summary of Bioreactor Design and Operation...
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 Fall '11
 Kennell

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