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lecture notes-metabolism pathways-complete notes-2009

lecture notes-metabolism pathways-complete notes-2009 -...

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Metabolic Pathways - Overview of metabolism pathways - Catabolism - Anabolism - Bioenergetics - Important metabolic pathways - Catabolism: - Glucose catabolism - aerobic pathway - anaerobic pathway - Hydrocarbon - Nitrogen compounds - Anabolism: - Photosynthesis - Biosynthesis
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Metabolic Pathways Metabolism: a complete set of chemical reactions that occur in living cells, allowing cells to grow and reproduce, maintain their structures, and respond to their environments. Major challenges in bioprocess development: To select an organism that can efficiently make a given product or digest wastes in the Environment. It is important to understand the metabolic pathways.
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Metabolic Pathways - Overview of metabolism pathways Metabolism can be subdivided by - Catabolism : The intracellular process of degrading a compound into smaller and simpler products and generating energy. Glucose to CO 2 , and H 2 O, protein to amino acids. - Anabolism : the synthesis of more complex compounds and requires energy. Synthesis of small molecules (amino acids, nucleotides, fatty acids and sugars) and complex compounds (glycan (polysaccharide), DNA, RNA, and lipids.)
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Major Metabolic Pathways in a Bacterial Cell ( M.Shuler, 2002 )
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Metabolic Pathways - Bioenergetics Sunlight Photosynthesis by autotrophs : CO 2 + H 2 O → carbohydrates Anabolism requiring energy Catabolism generating energy, e.g ATP Autotrophs or heterotrophs
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Metabolic Pathways - Bioenergetics - Energy is mainly stored or transferred by adenosine triphosphate (ATP). Other energy carrying compounds include GTP, UTP and CTP.
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Metabolic Pathways Bioenergetics - Reducing power: supply hydrogen atom in biosynthesis. Nicotinamide Adenine Dinucleotide (NADH) Flavin Adenine Dinucleotide ( FADH2) NADH and FADH2 are major electron carriers in the oxidation of fuel molecules and for ATP generation.
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