lecture notes-molecular biology-cell regulation

Lecture - Metabolic Regulation Genetic level Cellular level Enzyme activity Metabolic Regulation Genetic Level Regulation Control which protein is

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Metabolic Regulation - Genetic level - Cellular level : - Enzyme activity
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Metabolic Regulation Genetic Level Regulation : Control which protein is synthesized through adjusting the rate of transcription of that gene: Feedback repression : The end product of enzymatic activity accumulates and blocks transcription . For repression, the repressor protein is required which can bind to the operator region and hinder RNA polymerase binding. The repressor protein can block transcription only when bound to the co-repressor (typically the end product of the pathway).
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m-RNA RNA polymerase repressor Promoter Operator Gene 1 Gene 2 Gene 3 Normal Transcription RNA polymerase repressor Promoter Operator Gene 1 Gene 2 Gene 3 corepressor Transcription Blocked DNA template inactive active DNA template
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Genetic Organization of the Tryptophan Operon DNA template encoding repressor encoding related enzymes for tryptophan synthesis Only when the repressor binds with tryptophan, it can bind on the operator region and block the transcription. Operon : In prokaryotes, a set of genes, encoding proteins with related functions, under the control of a single promoter- operator.
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Genetic Level Regulation : Induction : a metabolite ( often a substrate for a pathway) accumulates and acts as an inducer of transcription . The inducer
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This note was uploaded on 02/13/2012 for the course CHM 3210 taught by Professor Kennell during the Fall '11 term at University of Florida.

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Lecture - Metabolic Regulation Genetic level Cellular level Enzyme activity Metabolic Regulation Genetic Level Regulation Control which protein is

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