CTools011911lecture06

CTools011911lecture06 - Lecture 6: Wednesday, January 19,...

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Unformatted text preview: Lecture 6: Wednesday, January 19, 2011 Biology 172 Todays Outline Announcements This Week in Discussion: Detergents, quiz lectures 4, 5 Exam 1 is Mon., Jan. 31, 6-8 pm 150 pts multiple choice & short answer questions Covers lectures 1-10 Review session in class on Mon., Jan. 31 Enzyme Regulation Enzymes and Drugs Lipids Biological Membranes- Fluid mosaic model - Membrane structure Enzyme Regulation Environmental Factors Irreversible Inhibition: Inhibitor binds to enzyme by covalent bonds , get altered conformation Physical: super-glue on hands Chemical: nerve gas Reversible Inhibition Allosteric Enzymes Enzyme Regulation Environmental Factors Irreversible Inhibition Reversible Inhibition Competitive inhibitor Noncompetitive inhibitor Allosteric Enzymes Competitive inhibition directly blocks the active site. Competitive inhibitor Substrate Enzyme When the regulatory molecule binds to the enzymes active site, the substrate cannot bind Compete with S for active site of enzyme Often resemble S Bind to enzyme with weaker bonds Hersheys hugs - look a lot like kisses Competitive Inhibitors Vmax is same. KM is greater. Affinity is less. At very high [S], S out-competes the inhibitor; Vmax is the same Noncompetitive Inhibitors Bind to site distinct from active site of enzyme Do NOT resemble S Vmax is lowered Noncompetitive Inhibitors Vmax is lower. Very high [S] does not change the effect of the inhibitor. reaction rate Substrate concentration [S] Inhibitors of Enzyme Action: Non-covalent modifications Effect decreases with increasing substrate concentration Is not affected by changes in substrate concentration Enzyme Regulation Environmental Factors Irreversible Inhibition Reversible Inhibition Competitive inhibitor Noncompetitive inhibitor Allosteric Enzymes Substrate Enzyme Regulatory molecule Activating the enzyme Inactivating the enzyme When the regulatory molecule binds to a...
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CTools011911lecture06 - Lecture 6: Wednesday, January 19,...

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