CTools021111lecture15

CTools021111lecture15 - Lecture 15: Friday, February 11,...

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Unformatted text preview: Lecture 15: Friday, February 11, 2011 Biology 172 Todays Outline Announcements Discussion Next Week: Central Dogma Quiz on Lectures 14, 15, 16 What Do Genes Do? What is a Gene (DNA or Protein)?- Griffiths experiment- Avery et al. experiment- Hershey & Chase experiment DNA Structure- The Double Helix: Watson & Crick Model Archibald Garrod (1909) Alkaptonuria- defect in biochemical enzyme causes urine to turn black Genes must be related to enzymes Conclusions Genes are units that cannot be broken apart Genes specify proteins (enzymes!) 1 Gene specifies 1 protein (mostly) Genetic Information The Chromosomal Theory of Inheritance (1900) The genetic material is located in chromosomes.- passed from parent to offspring What chemical in the cell bears the genetic information?- determines the characteristics (phenotype) of the organism chromosomes contain only DNA and protein Todays Outline Introductory Remarks: What Do Genes Do? What is a Gene (DNA or Protein)?- Griffiths experiment - Avery et al. experiment- Hershey & Chase experiment DNA Structure- The Double Helix: Watson & Crick Model Friedrich Miescher studied chemical composition of cell nuclei. Found protein + X X was acidic material he named nuclein because it came from nuclei. He isolated white blood cells from soldiers bandages because pus cells with high ratio of nuclear to cytoplasmic contents. Evidence for DNA as the Genetic Material 1. Transformation of Streptococcus - Griffiths experiment Rough colonies (R) Smooth colonies (S) S strain is virulent R strain is benign Evidence for DNA as the Genetic Material 1. Transformation of Streptococcus - Griffiths experiment Evidence for DNA as the Genetic Material pathogenic nonpathogenic Dead S bacteria contained a substance that...
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This note was uploaded on 02/13/2012 for the course BIO 172 taught by Professor Clark during the Winter '08 term at University of Michigan.

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CTools021111lecture15 - Lecture 15: Friday, February 11,...

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