Lecture 23 W11 - Lecture 23 (3-11-11) Notes I. Some...

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Lecture 23 (3-11-11) Notes I. Some fundamental differences in regulation of gene expression in eurkaryotes from proks A. Transcriptional regulation – occurs in the nucleus and involves chromatin B. RNA processing – newly made mRNAs are capped at the 5’ end, introns are removed and polyadenylated at the 3’ end C. mRNAs are transported out of the nucleus and their stability can be regulated (this occurs in prokaryotes as well though the mechanisms are different) D. Translation – occurs in the cytoplasm E. Post-translational regulation – controlling the activity of a protein after it is synthesized II. Chromatin A. A complex of DNA and proteins that organizes the huge amount of DNA into the relatively small nucleus 1. the state of this chromatin can be regulated (often called chromatin remodeling) B. The nucleosome is the basic unit of chromatin 1. DNA wrapped around an eight subunit complex of positively charged proteins called histones. C. Nucleosomes are then organized into 30 nm-fibers, which are then attached to protein
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Lecture 23 W11 - Lecture 23 (3-11-11) Notes I. Some...

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