lecture 28 W11 - Lecture 28 (3/23/11) - Cancer Biology...

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Unformatted text preview: Lecture 28 (3/23/11) - Cancer Biology Todays topics 1) Describe the properties of cancer cells 2) Review the types of mutations that occur in cancers 3) Recognize the difference between a tumor suppressor and an oncogene 4) Cover some anti-cancer therapies Molecules; Chemical bonds; Free energy Lipids Amino acids nucleotides carbohydrates membranes proteins Membrane transport Membrane proteins cytoskeleton enzymes DNA RNA Metabolism Sugar transport Electrolyte transport Kidney Nerve cells Muscle & movement Transporters and pumps Receptors Cell-cell communication Chemical signaling development Replication transcription translation Glycolysis Fermentation Krebs cycle Photo- Synthesis & Calvin cycle Cell cycle Regulation of transcription biotechnology genomics Microbes & viruses Biology 172 flowchart (lecture 28) cancer epigenetics How does a cell become cancerous? Mutations that promote the cancer phenotype accumulate over time Loss of function mutations in tumor suppressor genes promote cancer RB +- wildtype RB-- LOF mutant Several ways that gain of function mutations can activate oncogenes e.g., GTPase Mutant in Ras Oncogene product normal Oncogene product misregulated Receptor tyrosine kinases that promote cell growth can be constitutively activated by mutation Tyrosine kinase receptor protein Tyrosine kinase receptor gene ATG TGA NH3 COOH Kinase domain Ligand binding domain transmembrane domain ligand P P inactive kinase active kinase Normal situation Growth signal Activation of a receptor tyrosine kinase by mutation...
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lecture 28 W11 - Lecture 28 (3/23/11) - Cancer Biology...

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