Lecture 36 notes W11

Lecture 36 notes W11 - Lecture 36 Notes I Protection...

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Lecture 36 (4-13-11) Notes I. Protection against pathogens A. Barriers 1. Skin is a physical and chemical barrier (dry and acidic) 2. Mucus lines the digestive, respiratory, urinal and genital tracts. 3. Tears and ear wax also contribute B. Innate immunity 1. Cellular response to any pathogen C. Acquired immunity 1. Cellular response to particular pathogen. II. Innate immunity A. Mediated by leukocytes (derived from the bone marrow). 1. Mast cells – release histamine (dilates blood vessels) and other chemicals that can constrict blood vessels near a wound. 2. Neutrophils – secrete lysozyme (breaks down bacterial cell wall) and reactive oxygen species (H 2 O 2 ) and phagocytize foreign debris. 3. Macrophages – release chemokines (to attract cells involved in immune response and wound healing) and can phagocytize foreign debris. III. The inflammatory response A. Bacteria and other pathogens enter a wound. B. Platelets and blood clotting proteins make a physical barrier against these pathogens. C. Macrophages sound the alarm by releasing chemokines to recruit other immuno cells. D. Mast cells constrict vessels at the wound and dilate vessels nearby (to increase delivery of
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This note was uploaded on 02/13/2012 for the course BIO 172 taught by Professor Clark during the Winter '08 term at University of Michigan.

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Lecture 36 notes W11 - Lecture 36 Notes I Protection...

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