Recombination - reflects the physical distance separating...

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Double stranded break formation
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Resection 5’ end on each side of break are degraded to produce two 3’ single stranded tails
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First strand invasion RecA binds 3’ tail and double helix allowing invasion and migration
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Formation of Holliday junctions New DNA synthesis forms two X structures - Holliday junctions
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The Holliday intermediate Interlocked nonsister chromatids disenguage. Two resolutions are possible
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Gene conversion The two strands in the heteroduplex may not be a perfect match DNA repair or replication resolves the mismatch and may result in gene conversion
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met - arg - mal - met + arg + mal +
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Independent assortment Linkage Separation by recombination
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Fig. 5.1
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Parental class outnumbers recombinant class demonstrating linkage Linkage in an autosomal gene
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Recombination frequencies for pairs of genes reflect distance between them Recombination frequency (RF)
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Unformatted text preview: reflects the physical distance separating two genes 1 RF = 1 map unit (or 1 centiMorgan) Mapping: Locating genes along a chromosome Two-point crosses: comparisons help establish relative gene positions Genes are arranged in a line along a chromosome Mapping: Locating genes along a chromosome Three Point Crosses: A faster more accurate method to map genes Analyzing the results of a three point cross Look at two genes at a time and compare to parental 252 + 241 + 131 + 118 4197 X 100 = 17.7 m.u. vg b distance 252 + 241 + 13 + 9 4197 X 100 = 12.3 m.u. vg pr distance 131 + 118 + 13 + 9 4197 X 100 = 6.4 m.u. b pr distance Numbers dont always add up - Need to correct for double crossovers w Genes associated by linkage relationships are known as linkage groups...
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Recombination - reflects the physical distance separating...

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