{[ promptMessage ]}

Bookmark it

{[ promptMessage ]}

ferrin-infoviz - Informatics and Visualization Tools for...

Info iconThis preview shows pages 1–18. Sign up to view the full content.

View Full Document Right Arrow Icon
Informatics and Visualization Tools for Structural Genomics Research Tom Ferrin, Ph.D. Departments of Pharmaceutical Chemistry and Biopharmaceutical Sciences Resource for Biocomputing, Visualization, and Informatics University of California, San Francisco UCB InfoViz seminar April 14, 2004
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Resource for Biocomputing, Visualization, and Informatics The RBVI is a NIH/NCRR Biomedical Technology Research Center We create innovative computational and visualization- based data analysis methods and algorithms, turns these into easy-to-use software tools, and apply these tools for solving a wide range of genomic and molecular recognition problems within the complex sequence structure function triad
Background image of page 2
Application areas Gene characterization and interpretation Drug design Variation in drug response due to genetic factors Protein engineering Biomaterials design Bioremediation Prediction of protein function from sequence and structure
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Tony Reichhardt Nature 399:517-520 10 June 1999 “It’s sink or swim as a tidal wave of data approaches Petabyte (1,000 terabytes) Exabyte (1,000 petabytes) Zettabyte (1,000 exabytes) Yottabyte (1,000 zettabytes)
Background image of page 4
“Many biologists are still in denial, never having faced the amount of information now pouring into databases such as Genbank and SwissProt… They haven’t really thought about how they’re going to use all this data...” Ibid .
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
The Growing Gap in Functional Knowledge 0 500,000 1,000,000 1,500,000 2,000,000 2,500,000 3,000,000 1975 1980 1985 1990 1995 Publications DNA sequences EST sequencing begun Rapid DNA sequencing invented
Background image of page 6
Sample RVBI projects New methods for large-scale data collection, storage, analysis, and presentation for polymorphism (SNP) genotyping project Extensible visualization tools for comparative studies of protein sequence, structure, and function
Background image of page 7

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Fortune - Oct 30, 2000
Background image of page 8
Case Report #1: Michael Adams-Conroy Young child born to abusive mother, adopted at age 3, with signs of fetal alcohol syndrome, obsessive-compulsive disorder, Tourette’s syndrome, and attention-deficit hyperactivity disorder. Prescribed Prozac to help control emotional outbursts. Child dies suddenly; toxicology tests show massive overdose of Prozac. Adoptive parents investigated for homicide and their other two children put into protective custody.
Background image of page 9

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Michael Adams-Conroy (continued) Sharp-eyed psychiatrist notices unusually high levels of other metabolites in toxicology report, indicating child may have had an enzyme deficiency inhibiting Prozac from being metabolized normally. Subsequent genetic testing showed child had defect in 2D6 gene which resulted in abnormal liver enzyme that metabolizes antidepressants. Adoptive parents exonerated.
Background image of page 10
Case Report #2 Patient: 3-year old boy Diagnosis: Acute Lymphoblastic Leukemia (ALL) Standard therapy: 6-mercaptopurine (6-MP) Result: Adverse Drug Reaction leading to acute bone marrow suppression
Background image of page 11

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Normal Mechanism of Action 6-MP 6-METHYLMERCAPTOPURINE CH 3 S S TPMT 6-THIOGUANINE NTs
Background image of page 12
TPMT TPMT X THIOPURINE METHYLTRANSFERASE (TPMT) GENES ARE DEFECTIVE IN 1:300 PEOPLE
Background image of page 13

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
This leads to elevated levels of Thioguanine Nucleotides 6-MP 6-METHYLMERCAPTOPURINE CH 3 S S TPMT 6-THIOGUANINE NTs X
Background image of page 14
ADVERSE DRUG REACTION (ADR) THERAPEUTIC RESPONSE NO RESPONSE PEOPLE DIFFER IN THEIR RESPONSE TO DRUGS
Background image of page 15

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
TESTING FOR TPMT GENES IS NOW AVAILABLE
Background image of page 16
CHILDREN WITH DEFECTIVE TPMT GENES SHOULD RECEIVE A LOWER DOSE OF 6-MP
Background image of page 17

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Image of page 18
This is the end of the preview. Sign up to access the rest of the document.

{[ snackBarMessage ]}