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Unformatted text preview: Knockout vascular Thursday, October 11, 2007 9:04 AM Secreted proteins around blood vessels(caps) that regulate what goes in and out Tight epithelials to monitor what passes Most pronounced in blood brain barrier Smooth muscle vein smaller than artery Cells are predetermined Angioplasts induced to become vessels o Specific growth factors o Cause cells to line up and make a vessel o Angiogenesis- arteries and veins become very differentiated Molecularly, morphological distinct from one another Studied nerve development relationship to vascular? ephB4(receptor, kinase) and Ephrin-B2 (ligands) o Phosphate group activates protein o Receptors sit at head of huge cascade o Protein-cell cycle-transcription o Expansion of these molecules...
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