Knockout Mice Notes

Knockout Mice Notes - Knockout… vascular Thursday 9:04 AM...

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Unformatted text preview: Knockout… vascular Thursday, October 11, 2007 9:04 AM •€€€€€€€€ Secreted proteins around blood vessels(caps) that regulate what goes in and out •€€€€€€€€ Tight epithelials to monitor what passes •€€€€€€€€ Most pronounced in blood brain barrier •€€€€€€€€ Smooth muscle vein smaller than artery •€€€€€€€€ Cells are predetermined •€€€€€€€€ Angioplasts induced to become vessels o Specific growth factors o Cause cells to line up and make a vessel o Angiogenesis- arteries and veins become very differentiated •€€€€€€€€ Molecularly, morphological distinct from one another •€€€€€€€€ Studied nerve development relationship to vascular? •€€€€€€€€ ephB4(receptor, kinase) and Ephrin-B2 (ligands) o Phosphate group activates protein o Receptors sit at head of huge cascade o Protein-cell cycle-transcription o Expansion of these molecules...
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Knockout Mice Notes - Knockout… vascular Thursday 9:04 AM...

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