Clicker_weeks1through4

Clicker_weeks1through4 - Lecture 1 Pseudo-clicker ques2on:...

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Unformatted text preview: Lecture 1 Pseudo-clicker ques2on: If a mouse has a dominant phenotype (P-), how would you determine the genotype: is it homozygous (PP) or heterozygous (Pp)? 1) Cross it to a homozygous dominant mouse: (PP) 2) Cross it to a mouse with the dominant phenotype but unknown genotype: (P-) 3) Cross it to a mouse with the recessive phenotype: (pp) 4) Cross it to a heterozygous dominant mouse (Pp) 5) It cannot be determined Pseudo-clicker ques2on: If a mouse has a dominant phenotype (P-), how would you determine the genotype: is it homozygous (PP) or heterozygous (Pp)? Answer: 3. Cross it to a mouse with the recessive trait (pp) Explana-on: This is a test cross. If there are many offspring, all with the dominant trait, the tested mouse is homozygous. If some offspring have the recessive trait (half would be expected), the tested mouse is heterozygous. Lecture 2 Clicker Ques2on: Wet earwax is dominant to dry earwax. Sam has wet earwax. Sam's mother has dry earwax. What is Sam's genotype? A) B) C) D) E) WW Ww ww WW or Ww Can't be determined from the informa2on provided Wet earwax is dominant to dry earwax. Sam has wet earwax. Sam's mother has dry earwax. What is Sam's genotype? B) Ww The genotypes WW and Ww both result in the wet phenotype. Only the genotype ww results in the dry phenotype. Sam's mother must be ww. Therefore, Sam must be Ww. Clicker Ques2on: What would happen if gg peas died (weren't formed)? What percentage of the F2 would be yellow and round? A) 9/12 B) 3/12 C) 9/16 D) 4/16 E) 3/16 What would happen if gg peas died (weren't formed)? What percentage of the F2 would be yellow and round? A) 9/12 Lecture 3 Clicker Ques2on: How many different phenotypes are seen in F2 of trihybrid cross? How many different phenotypes are seen in F2 of trihybrid cross? Clicker Ques2on: How many different genotypes are seen in F2 of trihybrid cross? How many different genotypes are seen in F2 of trihybrid cross? Clicker Ques2on: How many different types of gametes can be formed by the genotype DdEeFF ? A) 2 B) 3 C) 4 D) 6 E) 8 How many different types of gametes can be formed by the genotype DdEeFF ? C) 4 The first two loci are heterozygous and have different segrega2ng alleles, whereas the third locus has only one allele. Therefore the possible number of gametes is 2 x 2 x 1. The formula 2n can be used to determine the number of gametes, when n = the number of heterozygous traits. The possible gametes are DEF, dEF, DeF, and deF. Lecture 4 Clicker Ques2on: What percentage of the progeny of this cross will display all three recessive phenotypes? What percentage of the progeny of this cross will display all three recessive phenotypes? Clicker Ques2on: Clicker Ques2on: In a plant species, if the B allele (blue flowers) and the b allele (white flowers) are incompletely dominant (Bb is light blue), what offspring ra2o is expected in a cross between a blue-flowered plant and a white- flowered plant? A) 1/4 blue: 1/2 light blue: 1/4 white B) 1/2 blue: 1/2 white C) All light blue D) 3/4 blue: 1/4 white E) 1/3 blue: 1/3 light blue: 1/3 white In a plant species, if the B allele (blue flowers) and the b allele (white flowers) are incompletely dominant (Bb is light blue), what offspring ra2o is expected in a cross between a blue-flowered plant and a white- flowered plant? C) All light blue The cross is BB bb, which would yield all Bb (light blue) offspring. Clicker Ques2on: If a mother has type A blood and her son has type O blood, what are the possible blood types of her son's father? A) Type O only B) Types A or O C) Types B or O D) Types A, B, or O E) Any blood type If a mother has type A blood and her son has type O blood, what are the possible blood types of her son's father? D) Types A, B, or O The father must carry the IO allele, so he could be IOIO (type O), IAIO (type A), or IBIO (type B). Lecture 5 Ques2on: Which individuals determines the recessive mode of inheritance? Which individual determines the X-linked mode of inheritance? A. B. C. D. I-2, II-2 II-5, II-2 II-2, II-4 I-4, III-1 Ques2on: Which individuals determines the recessive mode of inheritance? Which individual determines the X-linked mode of inheritance? A. I-2, II-2 B. II-5, II-2 C. II-2, II-4 D. I-4, III-1 Could also argue III-8 Ques2on: Which individual rules out a dominant trait? 1 2 2 3 4 I II III IV V 1 2 1 A. B. C. D. IV-5 III-3 III-2 IV-1 Ques2on: Which individual rules out a dominant trait? 1 2 2 3 4 I II III IV V 1 2 1 A. B. C. D. IV-5 III-3 III-2 IV-1 Ques2on: What are genotypes and ra2os of the progeny if the region is paternally imprinted instead of maternally imprinted? Cross I: Cross I-R: A * a A A A A A X AA AA X Aa * a Aa A= wt allele a= mut allele A. B. C. D. Cross 1: wt: mut 1:1, Cross I-R: wt:mut 1:0 Cross 1: wt: mut 1:0, Cross I-R: males mut, 100% females wt Cross 1: males mut, 100% females wt, Cross I-R: wt:mut 1:0 Cross 1: wt: mut 1:0, Cross I-R: wt:mut 1:1 Ques2on: What are genotypes and ra2os of the progeny if the region is paternally imprinted instead of maternally imprinted? Cross I: Cross I-R: A * a A A A A A X AA AA X Aa * a Aa A= wt allele a= mut allele A. B. C. D. Cross 1: wt: mut 1:1, Cross I-R: wt:mut 1:0 Cross 1: wt: mut 1:0, Cross I-R: males mut, 100% females wt Cross 1: males mut, 100% females wt, Cross I-R: wt:mut 1:0 Cross 1: wt: mut 1:0, Cross I-R: wt:mut 1:1 Lecture 6 Marfan Syndrome is an autosomal dominant trait. Which of these diagrams could represent a pedigree for Marfan Syndrome? A) 1 2 Clicker Ques2on: B) 1 4 5 2 1 2 3 1 2 3 4 5 C) 1 2 D) 1 2 1 2 3 4 5 1 2 3 4 5 E) B or D Marfan Syndrome is an autosomal dominant trait. Which of these diagrams could represent a pedigree for Marfan Syndrome? A) 1 2 B) 1 4 5 2 1 2 3 1 2 3 4 5 C) 1 2 D) 1 2 1 2 3 4 5 1 2 3 4 5 E) B or D Clicker Ques2on: Duchenne muscular dystrophy is caused by a recessive X- linked allele. A man with this disorder _____. A) could have inherited it from either parent B) must have inherited it from his mother C) must have inherited it from both parents D) can pass it along to all of his children E) can pass it along to only his sons Duchenne muscular dystrophy is caused by a recessive X- linked allele. A man with this disorder _____. B) must have inherited it from his mother The man must carry only one copy of the allele on his X chromosome, which he must have inherited from his mother. He would have inherited a Y chromosome from his father. He would pass that X chromosome on to only his daughters. Clicker Ques2on: Which statement best describes human sex determina2on? A) Females are heterogame2c. B) Individuals with a Y chromosome are male. C) Individuals with two X chromosomes are female. D) Individuals with at least twice as many X chromosomes as Y chromosomes are female. E) Individuals with one X chromosome are male. Which statement best describes human sex determina2on? Answer: B) Individuals with a Y chromosome are male. Explana-on: This is the best answer, because XXY individuals are male and XO individuals are female. Clicker Ques2on: In which of the following individuals would you find one Barr body per cell? A) Karyotypically normal male B) Klinefelter male C) XYY male D) Turner syndrome female E) None of the above In which of the following individuals would you find one Barr body per cell? Answer: B) Klinefelter male Explana-on: A Barr body is an inac2vated X that compensates for X chromosome dispari2es (dosage compensa2on). A Klinefelter male is XXY and therefore one X chromosome is inac2vated. All the other individuals listed among the answers only have one X chromosome. Lecture 7 Clicker Ques2on: Which of the following best describes the Lyon hypothesis? A) Barr bodies are inac2vated X chromosomes. B) The paternal X chromosome of a female is inac2vated in an early embryonic stage. C) The maternal X chromosome of a female is inac2vated in an early embryonic stage. D) One of the two female X chromosomes is randomly inac2vated in an early embryonic stage. E) Each cell of a female randomly inac2vates one X chromosome shortly ager mitosis. Which of the following best describes the Lyon hypothesis? D) One of the two female X chromosomes is randomly inac-vated in an early embryonic stage. Either the paternal or maternal X chromosome is inac2vated at random, and all progeny cells retain the inac2va2on. Clicker Ques2on: A human individual with 45 chromosomes is an example of: A) monosomy. B) trisomy. C) monoploidy. D) diploidy. E) triploidy. A human individual with 45 chromosomes is an example of: Answer: A) monosomy. Explana-on: The normal human chromosome complement is 46. With 45 chromosomes, one member of one chromosomal pair is missing; this is a monosomy. Clicker Ques2on: Pericentric inversions: A) do not include the centromere in the inverted region. B) change the arm ra2o of the chromosome. C) are usually lethal in homozygous form. D) result in acentric and dicentric chromosomes ager crossing over within the inverted region in a heterozygote. E) All of the above. Clicker Ques2on: Pericentric inversions: Answer: B) change the arm ra2o of the chromosome. Explana-on: Inversions in general do not cause viability problems in homozygous or heterozygous form. The rest of the incorrect choices are true of paracentric, but not pericentric, inversions. Lecture 8 Complementa2on analysis comparing wingless mutants Clicker Ques2on: What is the result of this test? A) fail to complement; same gene B) complement; different genes Complementa2on analysis comparing wingless mutants What is the result of this test? A) fail to complement; same gene B) complement; different genes Complementa2on analysis comparing wingless mutants Clicker Ques2on: What is the result of this test? A) fail to complement; same gene B) complement; different genes Complementa2on analysis comparing wingless mutants What is the result of this test? A) fail to complement; same gene B) complement; different genes Clicker Ques2on: What ra2o of gametes is observed with independent assortment? What ra2o of gametes is observed with independent assortment? Clicker Ques2on: How many different types of gametes will be formed by this female? How many different types of gametes will be formed by this female? m: body SIZE ...
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