Lec6_illustrations

Lec6_illustrations - LECTURE 6 Thursday, January 26 Sex...

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LECTURE 6 Thursday, January 26 Sex determination and sex chromosomes • Announcements/reminders/comments • Review from lecture #5 • Sex-limited and sex-influenced traits • Sex chromosomes and sex determination • Dosage compensation/X-inactivation • Tips for the midterm
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Announcements/Reminders Guidelines for clicker points: ted.ucsd.edu Guidelines for section points: ted.ucsd.edu Guidelines for problem set points: ted.ucsd.edu Get your ?s answered on the discussion board Get your ?s answered in section Get your ?s answered at office hours Assignment #3 was posted on ted.ucsd.edu today
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Comments from conference: Genetics in action
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Marfan Syndrome • Connective tissue disorder • Autosomal dominant trait • Can be inherited or spontaneous • Caused by mutations in FBN1 (fibrillin 1)
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Genetic Connections: Marfan and Stiff Skin Syndromes • Marfan syndrome is caused by mutations in FBN1 • Stiff skin syndrome is caused by mutations in FBN1 • Using mouse genetics to model both diseases, gaining insight into basis of disease and therapeutic strategies
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Review from lecture #5 • X-linked traits • Imprinted traits • Mitochondrial inheritance • Maternal effect • Expressivity/penetrance
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X-linked mutations
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Eye color is an X-linked trait in Drosophila
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X-linked mutations
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Hallmarks of recessive X-linked traits • Trait usually not distributed equally between males and females • Affected females pass trait to all sons • Affected males never pass trait to sons – Affected females pass trait to all sons • affected mother passes trait to ALL sons – never father to son
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inheritance for pedigrees 1 2 1 2 3 4 5 6 1 2 1 2 3 4 5 6 1 2 1 2 3 4 5 6 1 2 1 2 3 4 5 6
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Lec6_illustrations - LECTURE 6 Thursday, January 26 Sex...

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