Lec8_illustrations

Lec8_illustrations - LECTURE 8 Thursday, February 2 Mapping...

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• Announcements/reminders • Complementation (Section 4.9) • Mapping genes (Sections 7.1-7.2) • Linked genes • Recombination frequency LECTURE 8 Thursday, February 2 Mapping genes
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What do geneticists actually do? • Very generally speaking… • Geneticists identify interesting mutant alleles (in nature or in the lab). • Through analysis of these alleles, geneticists gain insight into: - the functions of important genes - the modes of inheritance of specific traits - the genetic basis for certain diseases
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After identifying a collection of interesting alleles… • How many different genes are represented by these mutant alleles? • How many genes control the trait of interest? • Perform complementation analysis to test the relationship between alleles…
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Complementation analysis • Allows one to determine if two mutant alleles represent defects in the same gene – Screen for mutant phenotypes – Find 2 different mutant alleles with same phenotype • mutant allele a and mutant allele b • Are a and b defects in the same gene?
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Two different wingless mutants in Drosophila (fruit flies)
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Complementation: different genes
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Failure to complement: same gene
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For an allele of interest… • Where does this gene reside in the genome? • Use linkage analysis to map genes. • Linkage analysis demonstrates gene location by virtue of proximity to other linked genes.
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This note was uploaded on 02/10/2012 for the course BICD 100 taught by Professor Nehring during the Spring '08 term at UCSD.

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Lec8_illustrations - LECTURE 8 Thursday, February 2 Mapping...

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