14.5 - 14.5 Repairing Mistakes and Damages DNA is not only...

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14.5 Repairing Mistakes and Damages DNA is not only fast in its replication but it is for the most part very accurate, this accuracy is a matter of life or death. They ask how can the enzymes of DNA replication be as precise as they are? The first part of my section is about correcting mistakes in DNA synthesis o Hydrogen bonding is occurring between incoming deoxyribonucleotides when DNA polymerase is going down the parent DNA template. This DNA polymerase is selective to make sure the right base pairings occur o Mistakes in these pairings happen about 1/100,000 o They studied E. coli with high mutation rates to see why precision is important o The defect was in a portion of the polymerase III enzyme which is called the what? Answer: epsilon subunit o This subunit acts as an exonuclease which is an enzyme that removes deoxyribonucleotides from the ends of DNA strands o So when something makes an incorrect hydrogen bond, the epsilon subunit removes it o Which concluded that DNA polymerase III proofreads
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This note was uploaded on 02/12/2012 for the course SCI 2341 taught by Professor Yates during the Spring '11 term at Alabama.

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14.5 - 14.5 Repairing Mistakes and Damages DNA is not only...

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