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17.3 - 17.3 Mechanisms of Negative Control Discovery of the...

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17.3 Mechanisms of Negative Control: Discovery of the Repressor There are two general ways that transcription can be regulated: o Positive control Occurs when a regulatory protein binds to DNA and shuts down transcription o Negative control Occurs when a regulatory proteins binds to DNA and it triggers transcription Then it gives an example o The parking break is negative control and the gas pedal is positive control They figured out that the lacZ and lacY genes are controlled by both positive and negative control o They figured this out in the 1950s by Leo Szlisard o He said that the lacI gene produces an inhibitor that exerts negative control over the lacZ and lacy genes o What was this transcription inhibitor called? Answer: repressor Szilard and Monod said that lactose interacts with the repressor and makes it release from its binding site, it does this by removing negative control The repressor is the parking break and lactose is the driver that releases the
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