17.3 - 17.3 Mechanisms of Negative Control: Discovery of...

Info iconThis preview shows pages 1–2. Sign up to view the full content.

View Full Document Right Arrow Icon
17.3 Mechanisms of Negative Control: Discovery of the Repressor There are two general ways that transcription can be regulated: o Positive control Occurs when a regulatory protein binds to DNA and shuts down transcription o Negative control Occurs when a regulatory proteins binds to DNA and it triggers transcription Then it gives an example o The parking break is negative control and the gas pedal is positive control They figured out that the lacZ and lacY genes are controlled by both positive and negative control o They figured this out in the 1950s by Leo Szlisard o He said that the lacI gene produces an inhibitor that exerts negative control over the lacZ and lacy genes o What was this transcription inhibitor called? Answer: repressor Szilard and Monod said that lactose interacts with the repressor and makes it release from its binding site, it does this by removing negative control The repressor is the parking break and lactose is the driver that releases the
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 2
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 02/12/2012 for the course SCI 2341 taught by Professor Yates during the Spring '11 term at Alabama.

Page1 / 2

17.3 - 17.3 Mechanisms of Negative Control: Discovery of...

This preview shows document pages 1 - 2. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online