BI 405 Ch 1 PP - History of Immunology Athenian...

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History of Immunology Athenian Epidemic (430-426 BC) – Thucydides noted that survivors of the disease had immunity. Immunization against smallpox known in China from at least the 10th century AD. Dried the matter from pustules and inserted in nostrils. Turkey – variolation using crusts (scabs) from smallpox patient with mild form.
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Smallpox – 30% mortality rate. Late 1700’s killed: 10% of population 20% in cities 33% of all child deaths
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Lady Mary Wortley Montaque – (1718) had her children infected with smallpox. Charles Maitland – trial of smallpox variolation on six condemmed prisoners (August 1721). All survived after being exposed to smallpox. Repeated experiment on five orphaned children. Treated the daughters of the Prince of Wales. 2-3% of variolated persons died or contracted another disease (tuberculosis, syphilis). *case-fatality rate associated with variolation was 10 times lower than contracting the naturally
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Edward Jenner Cowpox – milkmaids that developed cowpox did not get smallpox. Used fluid from cowpox pustule to inoculate
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This note was uploaded on 02/12/2012 for the course BI 405 taught by Professor Winn during the Fall '11 term at Northern Michigan University.

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BI 405 Ch 1 PP - History of Immunology Athenian...

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