Lecture 3 Amino acids

Lecture 3 Amino acids - bases • Zwitterion: “hybrid...

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Protein Structure
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Stereoisomers of α amino acids The two stereoisomers of alanine, L-, and D- are non superimposable mirror images (enantomers) In proteins only L- configuration is found Cell are able to synthesize L isomers in stereospecific reactions.
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Amino acids are classified by R- group
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Nonstandard amino acids have important functions Selenocysteine: -derived from serine is found in handful of proteins. Ornithine and citrulline: are not part of the proteins, but rather are key intermediates in the synthesis of arginine.
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Amino acids are weak acids and
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Unformatted text preview: bases • Zwitterion: “hybrid ion” can act as acid (proton donor) or base (proton acceptor) • COOH + NH 3 Net Charge: +1 • COO-+ NH 3 Net Charge: 0 • COO - NH 2 Net Charge: -1 Isoelectric point, (pI) • At pH 5.97 glycine is fully ionized • It has no NET electric charge • Isoelectric point of glycine: pI=1/2 (pK a1 +pK a2 )=1/2(2.34+9.60)=5.97 At pH=5.97 glycine has no net charge! Biologically active peptides Oligomeric Protomeric • Hormones • Glutathione • Ubiquitin...
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This note was uploaded on 02/13/2012 for the course BIOT 6300 taught by Professor Blinder during the Spring '11 term at Northeastern.

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Lecture 3 Amino acids - bases • Zwitterion: “hybrid...

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