Lecture 4 Proteins

Lecture 4 Proteins - Three Dimensional Structure of the...

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Unformatted text preview: Three Dimensional Structure of the Proteins Three dimensional structure is determined by primary sequence. Function depends on the structure. Proteins exist in small number of conformations. Non covalent interactions stabilize the protein structure. Proteins share structural domains. Threedimensional structure of proteins Threedimensional structure of proteins is determined by it amino acid sequence. Function of the protein depends on its structure. Each protein has a unique or nearly unique structure. Noncovalent interactions are the most important forces stabilizing the three dimensional structure of the protein. There common structural patterns in vast protein architecture. Protein Conformation Spatial arrangement of atoms in the protein called conformation. Proteins can have several stable conformations, moving from one to the other should not involve breaking covalent bonds. Proteins in any of the functional, folded conformations are called, native Protein conformation is stabilized by weak interactions Hydrogen bonds with water play a key role in the protein conformation and solubility. Polar and charged groups with in the core of the protein must have hydrogen bonding partners. Substitution of one amino acid for another can have destabilizing effect. ...
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