Shao Lecture - Cellular and Molecular Biomechanics Jin-Yu...

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1 Cellular and Molecular Biomechanics Jin-Yu Shao Department of Biomedical Engineering Washington University, St. Louis, MO Biomechanics Mechanics Force Deformation or Rate of Deformation Biomechanics z 1960s – Organ, system z 1970s – Tissue Mechanics of body, system, organ, tissue, cell, & molecule, as well as synthetic biomaterials z 1980s –Ce l l z 1990s – Molecule Cellular & Molecular Biomechanics What is the difference? Force magnitude 1 pN = 10 -12 Newton 1 fN = 10 -15 Newton 1 nN = 10 -9 Newton 1 N =
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2 z Organ Biomechanics – Heart is like a pump (a few newtons) z Cellular Biomechanics Cellular & Molecular Biomechanics – Neutrophil is like a bag of water (a few piconewtons) – Deformation of an erythrocyte z Molecular Biomechanics – Von Willebrand factor (VWF) is like a nonlinear spring (tens of piconewtons) – A receptor-ligand bond is a like a “weird” spring Experimental Techniques z Atomic Force Microscope (AFM) z Optical Tweezers z Micropipette Aspiration Technique (MAT
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  • Spring '01
  • various
  • Force, Scanning Tunneling Microscope, von willebrand factor, Heinrich Rohrer, Cellular & Molecular Biomechanics, Micropipette Aspiration Technique

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Shao Lecture - Cellular and Molecular Biomechanics Jin-Yu...

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