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Unformatted text preview: Pharm Exam 3 Study Guide: Exam #3 Study Guide Psychosis/Schizophrenia 1. Be familiar with the symptoms of psychosis Positive- something added to a patients normal presentation o Hallucinations o delusions- grandiose, thought broadcasting, persecutory (believes they are being persecuted), bizarre o disorganized speech - not logical o disorganized / catatonic behavior (loss or hyperactivity of motor movements). Cognitive- decreased cognitive functioning o Poor concentration o Inability to focus o Living in the now o Concrete thinking o Memory disturbances o Inability to plan o Difficulty executing tasks o Poor abstraction o Impaired decision making Negative- something taken away from a patients normal presentation o Affective flattening- impaired outward display of emotions o Alogia (poverty of speech)- decreased speech fluency o Avolition- lack of motivation or drive o Anhedonia- loss of interest or pleasure o Asociality- lacking the capacity for social interaction 2. Be familiar with the epidemiology and course of schizophrenia, as well as myths about the disorder Myth: All schizophrenics are homeless and violent Myth: Split or multiple personality disorder = dissociative identity disorder 1% US population First Break - late onset, late adolescents to early adulthood Males=Females No ethnic differences Ideal Course: Initial psychotic episode quickly detected and treated and further illness is prevented by prophylactic treatment (age about 20 years) Chronic Relapse course: With each psychotic exposure there is a decrease in global function (there are several breaks and deteriorating with age) 3. Recognize the characteristic symptoms of schizophrenia and be able to differentiate between symptoms from different symptom clusters (i.e., positive, negative, and cognitive) Positive - something is added to a patients normal presentation (delusions, hallucinations, disorganized speech, catatonic behavior) Negative - something is taken away from a patients normal presentation o affective flattening - impaired outward emotions o anhedonia - loss of interest/pleasure o alogia - decreased speech fluency o avolition - lack of motivation/drive o asociality - lacking capacity for social interaction (inappropriately say mean things) cognitive - decreased cognition o poor memory,concentration, abstraction, decision making, inability to plan or complete tasks 4. Know what factors are required to diagnose a person with schizophrenia DSM-IV: 2+ persisting for at least a month (delusions, hallucinations, disorganized speech, grossly disorganized/catatonic behavior or negative symptoms (anhedonia, alogia, etc.) Symptoms will often affect function at work, socially, or self-care; often lasts 6 months o These 6 months may include prodromal or residual symptoms 5. Understand the effects of dopamine and serotonin receptor blockade by antipsychotic agents (both therapeutic effects and adverse events)...
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- Fall '09