Pharmacology Notes - Pharmacology Notes Depression Epidemiology of depression 17 of US population reports a major depressive episode in their

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Pharmacology Notes: Depression Epidemiology of depression 17% of US population reports a major depressive episode in their lifetime Depression occurs in women > men, about 2:1 Average age of onset: mid-20s o >50% of patients have first episode by age 40 years Duration: 6 months-2 years if left untreated o Episodes continue in up to 80% of untreated patients. (another episode, then another) No correlations between any particular ethnicity, socio-economic class or lifestyle and depression Depression is serious Most common diagnosis associated with psychiatric hospitalization Lifetime Suicide Risk: o 2% MDD treated as outpatient (Major Depressive Disorder) o 4% MDD treated as inpatient o 8% MDD with suicidal ideation/attempt treated as IP Depression associated with increased mortality rates in individuals 50+ years old Depression correlated to worse outcomes in chronic medical conditions such as diabetes mellitus 10 leading causes of disability worldwide Unipolar Depression 10.7% Iron deficiency anemia 4.7% Falls 4.6% Alcohol use 3.3% COPD 3.1% Bipolar Depression 3.0% Congenital abnormalities 2.9% Osteoarthritis 2.8% Schizophrenia 2.6%
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Obsessive compulsive d/o 2.2% Economic burden of clinical depression Estimated to be $30-60B Economic burden can result from o Lost workdays o Decreased productivity Increased healthcare system utilization What does depression look like? Depressed mood and/or anhedonia (inability to feel pleasure from any source) are hallmark symptoms Some patients present as sad, guilt-ridden, and hopeless Other patients will appear nervous, irritable, or agitated Some will complain of somatic problems (nothing is wrong with them physically, pain is caused by their depression, headaches, GI problems) Psychosis can accompany depression (other problem along with depression) Diagnosis of Major Depressive Disorder (MDD) DSM-IV criteria o Must meet 5 of following criteria with at least 1 being depressed mood or anhedonia: Depressed mood Anhedonia Weight loss or weight gain Insomnia or hypersomnia Psychomotor agitation Fatigue or decreased energy Feelings of worthlessness Decreased concentration Recurrent thoughts of death o Symptoms cause significant distress or impairment of function
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o Not better accounted for by bereavement after loss of a loved one (MDD diagnosed when there isn’t a reason for them to be depressed) o Symptoms persist for at least 2 weeks SIG E CAPS S leep I nterest G uilt E nergy C oncentration A ppetite P sychomotor agitation S uicide Medical causes of depression Depression associated with medical conditions o Hypothyroidism o Stroke, heart attack o Hepatitis C Depression associated with drugs o Alpha-interferon
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This note was uploaded on 02/14/2012 for the course PHR 338 taught by Professor Karboski during the Fall '09 term at University of Texas at Austin.

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Pharmacology Notes - Pharmacology Notes Depression Epidemiology of depression 17 of US population reports a major depressive episode in their

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