2012-01-25 Endocrinology and reproduction anatomy

2012-01-25 Endocrinology and reproduction anatomy -...

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Canine and Feline Endocrinology and Reproductive Anatomy Dr. N. Matthew Ellinwood, D.V.M., Ph.D. January 25, 2012 IOWA STATE UNIVERSITY
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Overview of Endocrinology Review of basic endocrinology to provide a better understanding of cyclicity Emphasis on hormones and the organs/tissues/cells involved
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Classification of Biochemical Compounds Almost all biochemical compounds can be classified into four categories Categories are: Nucleic acids Proteins (amino acids and their derivatives) Lipids Carbohydrates
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Terminology Endocrinology The study of hormones, the endocrine system, and the role in the physiology of the body. Endocrine secreted internally ductless applied to organs and structures that release their products into the blood or lymph, and to substances (hormones) that exert specific effects on other organs.
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Hormones a chemical substance produced in the body by an organ, cells of an organ, or scattered cells, having a specific regulatory effect on the activity of an organ or organs. For a hormone to exert its function to the body it must find its specific receptor. http://www.ftmguide.org/images/receptors.gif
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Hormone Categories Hormones can be classified biochemically, depending on their schemes Categories are: Peptides and proteins Luteinizing hormone (LH) Amino acid derivatives • Thyroid hormone (T 4 and T 3) Steroids Testosterone, estrogen, and progesterone Fatty acid derivatives Prostaglandins
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Anatomy Hypothalamus Pituitary Hypothalamo-pituitary axis Reproductive steroidogenic tissue Tissue that synthesizes steroids Testis: Leydig cells Ovary: ovarian follicle and corpus luteum Other players Sertoli cells
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Hormones GnRH LH FSH Testosterone Progesterone Estrogen
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Feedback Loops Negative feedback loop Example: In the male Testosterone has a negative feedback effect on GnRH Positive feedback loop Example: In female Estrogen has a positive feedback effect on GnRH
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Feedback Loops of the Male HYPOTHALAMUS ANTERIOR PITUITARY Hypothalamo-Pituitary Axis GnRH + FSH + LH Seminiferous tubule Leydig cells of the testis + Testosterone Sertoli cell - -
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Dynamic Feedback Loops of the Female: Depend on Stage of Cycle ANTERIOR PITUITARY
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2012-01-25 Endocrinology and reproduction anatomy -...

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