02 Digestion of Lipids

02 Digestion of Lipids - LipidDigestion...

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Lipid Digestion
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Monogastric Digestion Challenges Lipids are not water soluble Triglycerides too large to be absorbed Digestive solution Triglycerides mix with bile and pancreatic  secretions Emulsification and digestion
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Bile Produced in liver, stored in gallbladder Except horse Alkaline solution composed of: Bile salts Cholesterol Lecithin Bilirubin Responsible for fat emulsification Detergent action
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Mixed micelle formed by bile salts, triacylglycerols and pancreatic lipase.
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Digestion of Lipid Bile salts emulsify lipids Pancreatic lipase acts on triglycerides Triglycerides         sn -2 monoglyceride + 2 fatty  acids Pancreatic colipase Activated by trypsin Interacts with triglyceride and pancreatic lipase  Displaces bile to allow recycling Improves activity of pancreatic lipase
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Pancreatic Colipase Secreted from pancreas  as procolipase Activated (cleaved) by  trypsin Anchors lipase to the  micelle One colipase to one lipase (i.e., 1:1 ratio)
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Dietary Fat (large TG droplet ) Bile Salts Lipid emulsion Lipase 2-Monoglyceride  + 2 FFA
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Produces small lipid spheres Greater surface area Lipases attack TG at 1 and 3 positions G l y c e r o l Fatty Acid 1 Fatty Acid 2 Fatty Acid 3 Lipas e G l y c e r o l Fatty Acid
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This document was uploaded on 02/14/2012.

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02 Digestion of Lipids - LipidDigestion...

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