03 Metabolism of Lipids

03 Metabolism of Lipids - LipidMetabolism...

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Lipid Metabolism
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Lipid Transport in Blood Lipids are not  water soluble Blood is mainly water… Pack lipids in protein Chylomicrons Made in the enterocytes  (small intestine) Lipoproteins (lipids and proteins) VLDL, LDL, HDL made in  liver Groff & Gropper, 1999
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Release of Lipids at Liver Chylomicrons   chylomicron remnants Cholesterol-rich Taken up by liver and fatty acids are  metabolized
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Repackaging in the Liver Lipid is repackaged in the liver to VLDL or  very low density lipoprotein Lipoproteins are classified by density Lipoproteins transport lipid to the rest of the  body VLD L TG LDL TG HDL
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Lipoproteins Classified by density Protein:lipid ratio  More protein, increased density More lipid, decreased density Four classes of lipoproteins Chylomicrons VLDL LDL HDL Formed in  liver
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Lipoproteins Differ according to the lipid:protein ratio Density Chylomicrons Very-low–density lipoproteins ( VLDL ) High lipid content Low-density lipoproteins ( LDL ) Main cholesterol transport High-density lipoproteins ( HDL ) Low lipid content Low High
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Complex Source Density (g/ml) %Protein %TG a %PL b %CE c %C d %FFA e Chylomicron Intestine <0.95 1-2 85-88 8 3 1 0 VLDL Liver 0.95- 1.006 7-10 50-55 18-20 12-15 8-10 1 IDL VLDL 1.006- 1.019 10-12 25-30 25-27 32-35 8-10 1 LDL VLDL 1.019- 1.063 20-22 10-15 20-28 37-48 8-10 1 *HDL 2 Intestine, liver (chylomi crons and VLDLs) 1.063- 1.125 33-35 5-15 32-43 20-30 5-10 0 *HDL 3 Intestine, liver (chylomi crons and VLDLs) 1.125- 1.21 55-57 3-13 26-46 15-30 2-6 6 Albumin- FFA Adipose tissue >1.281 99 0 0 0 0 100 a Triacylglycerols, b Phospholipids, c Cholesteryl esters, d Free cholesterol, e Free fatty acids   *HDL2 and HDL3 derived from nascent HDL as a result of the acquisition of cholesteryl esters  
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Low Density Lipoproteins VLDL     LDL Cholesterol-rich Converted to bile salts  Carries cholesterol to tissues Used for membrane synthesis LDL ~  ‘bad cholesterol’ Associated with plaque formation in blood vessels High triglyceride and cholesterol content
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Removes cholesterol from: Cells Lipoproteins Deliver cholesterol to liver for excretion Converted to bile salts and excreted in feces HDL ~  ‘good cholesterol’ Is cholesterol ‘bad’ for you? Cell membranes, bile salts, synthesis of steroid 
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This document was uploaded on 02/14/2012.

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03 Metabolism of Lipids - LipidMetabolism...

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