Lect20.ProteinSynthesis

Lect20.ProteinSynthesis - LECT 20: PROTEIN SYNTHESIS AND...

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LECT 20: PROTEIN SYNTHESIS AND TRANSLATIONAL CONTROL High fidelity of protein synthesis from mRNA is essential. Mechanisms controling translation accuracy include very high fidelity of (1) tRNA charging with correct amino acid (2) codon-directed delivery of correct charged tRNA to ribosome Mechanisms for translation elongation and termination are very similar in prokaryotes and eukaryotes, but mechanisms of initiation are fundamentally different Translation of eukaryotic mRNAs can be regulated at the step of initiation by multiple mechanisms Secreted and membrane-spanning proteins are co-translationally delivered across membranes by “translocons” guided by signal and anchor sequences in the nascent polypeptide chain
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Transfer RNA Structure and Functional Domains
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Chemistry of tRNA Charging with Amino Acid
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tRNA Synthetase Achieves Fidelity Through Substrate Specificity and Editing A tRNA synthetase recognizes a specific tRNA by interaction with unique structural features of that tRNA,
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Lect20.ProteinSynthesis - LECT 20: PROTEIN SYNTHESIS AND...

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