Lect22.LipidsCholesterol

Lect22.LipidsCholesterol - LECT 22: LIPIDS, MEMBRANES, AND...

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Unformatted text preview: LECT 22: LIPIDS, MEMBRANES, AND CHOLESTEROL Lipids and cholesterol in the body derive from food intake and from de novo synthesis. Phospholipids are principle constituent of cell membranes, and specialized phospholipids participate in signal transduction pathways. Lipid and cholesterol synthesis intermediate anchors serve to attach certain proteins to membranes. Cholesterol is a membrane constituent needed in all cells. Bile acids used for intestinal fat uptake and nuclear hormones are synthesized from cholesterol. Cholesterol is only synthesized in the liver, so that all other tissues must receive cholesterol by trafficking through blood in the form of lipoprotein particles. Phospholipids Have Glycerol Backbone, Two Fatty Acids, and Phosphate Alcohol The Four Common Phospholipids Phosphatidylinositol(PI) has diverse functions. In addition to being a major membrane constituent, PI’s inositol ring can be phosphorylated to generate a signal transduction intermediate. PI can also be further modified to generate the GPI membrane anchor. Phospholipid Synthesis Uses CDP Intermediates Sphingosine Is a Fatty Amine Used to Generate the Specialized Lipid Sphingomyelin...
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This note was uploaded on 02/14/2012 for the course BIO 710L taught by Professor Goldfarb during the Fall '10 term at Iowa State.

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Lect22.LipidsCholesterol - LECT 22: LIPIDS, MEMBRANES, AND...

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