Lect24.CellSignaling

Lect24.CellSignaling - LECT 24: CELL SIGNAL TRANSDUCTION...

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LECT 24: CELL SIGNAL TRANSDUCTION Cells respond to molecular cues they receive: from neighboring cells or extracellular matrices (paracrine factors), from the circulation (hormones and metabolites), and from outside the body (sensory inputs). Some messengers, e.g. nuclear hormones, directly permeate the cell and interact with nuclear targets to effect responses. Most messengers bind to cell surface receptors, which transduce signals through intermediate proteins and messengers to ultimately effect changes in the cytoplasm and in the nucleus. The signal is often amplified during transduction, and feedback processes terminate or limit the response. Cell surface signaling receptors largely fall into several categories: …7-TM G-protein-coupled receptors (GPCRs) …Receptor protein kinases, including receptor tyrosine kinases (RTKs) …Others
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This note was uploaded on 02/14/2012 for the course BIO 710L taught by Professor Goldfarb during the Fall '10 term at Iowa State.

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Lect24.CellSignaling - LECT 24: CELL SIGNAL TRANSDUCTION...

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