Chapter 18 & 19 - Gene Regulation

Chapter 18 & 19 - Gene Regulation - GENE REGULATION...

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GENE REGULATION   PROKARYOTIC GENOME   use  substance s/synthesize  macrom ole cule s  just fast enough  to meet  needs   If substance/enzym e  need ed,  gene  is transcribed.     If substance/enzym e  not need ed,  gene  is turned  off   Allows  for cons ervation  of cell  resource s     Controlling  gene  expres sion  is one  method  of regulating  metabolism OPERON – Related  gene s  grouped  together  with one  promoter   Allows  for coordinated  control  of gene s  required  for metabolism.     One  switch  controls  more  than  one  gene   Can  be   inducible or   repressible   Not present  in eukaryotes Repres sible  and  inducible  enzym e s  = both  examples  of  NEGATIVE control  of a pathway Activating  the  repres s or  proteins  shuts  off the  pathway   POSITIVE  control  requires  that an  activator  molecule  switch  on  transcription OPERATORS- regions  of DNA that control  RNA acce s s  to promoter REPRESSOR - - regulatory  proteinsbinds  to operator   - turns  genes  off (negative  control  mechanis m)  
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This note was uploaded on 02/14/2012 for the course BIO 151 taught by Professor Grinblat during the Fall '08 term at Wisconsin.

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Chapter 18 & 19 - Gene Regulation - GENE REGULATION...

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