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BISC 330 Spring 2011 Lecture 1

BISC 330 Spring 2011 Lecture 1 - BISC 330L Biochemistry...

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BISC 330L: Biochemistry Spring Semester 2011 USC Lecture 1: Monday, 10 January 2011 1.Introduction to BISC 330 2.Review course syllabus 3.Start Chapter 1 material…
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BISC 330L BIOCHEMISTRY – USC SPRING 2011 Lecture Syllabus Topics : Biochemical bonds and reactions. Interactions with water molecules. Structure/function of DNA, RNA, proteins, lipids and carbohydrates. Enzyme kinetics and mechanisms. Enzyme cofactors and vitamins. Enzyme regulatory strategies. Cell structure, membranes and organelles. Protein biosynthesis and targeting to membranes and organelles. Glucose and O 2 production by photosynthesis in plant chloroplasts. Glucose oxidation and ATP production: glycolysis, citric acid cycle & oxidative phosphorylation. Ribose biosynthesis from glucose by pentose phosphate pathway. Mastery of these topics will provide students with a solid foundation in basic biochemical principles. Prerequisites: BISC 320L (Molecular Biology) and CHEM 322A (Organic Chemistry) Professors: Dr. John Petruska, Tel: (213) 740-5189, Email: [email protected] Office: RRI 119B, Office Hours: RRI 121 Tues/Thurs 11am - 1pm Dr. Steven Goodman, Tel: (213) 740-3867, Email: [email protected] Office: DEN 4108, Office Hours: TBA Dr. Matthew Michael, Tel: (213) 740-0553, Email: [email protected] Office: RRI 104B, Office Hours: TBA Dr. Angel P. Tabancay, Jr., Tel: (213) 740-6079, Email: [email protected] Office: ZHS 353, Office Hours: TBA Required Text : Berg, Tymocko & Stryer, BIOCHEMISTRY (6th ed., 2007) BISC 330L Lab Manual (available in USC Bookstore) Office Hours: Tues 9-11am ZHS 353
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TENTATIVE LECTURE SCHEDULE LECTURER, DATE SUBJECT CHAPTER AT, Jan 10 Biochemical bonds and reactions 1.1-1.3 12 Water, pH and acid/base equilibria 1.3 14 DNA discovery & genomic revolution 1.4 17 NO LECTURE - Martin Luther King Day 19 Amino acid structures & properties 2.1 21 Primary structure of proteins 2.2 24 Secondary structure 2.3 26 Tertiary & quaternary structures 2.4-2.6 28 Protein purification methods 3.1 31 Amino acid analysis & sequencing 3.2 AT, Feb 1 MIDTERM EXAM #1 4:00-4:50pm Rooms TBA 175 points AT, Feb 2 Protein structure determination 3.3-3.6 4 DNA & RNA structure & purification 4.1,4.2 7 DNA replication & gene expression 4.3-4.6
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JP, Feb 9 Intro. to thermodynamics & kinetics 8.1-8.3 11 Enzyme kinetics: M-M model 8.4 14 NO LECTURE - Presidents Day 16 Enzyme kinetics with inhibitors 8.5 18 Enzyme catalytic strategies 9.1-9.4 21 Enzyme regulatory strategies 10.1--10.4 23 Carbohydrate structures 11.1-11.4 25 Fatty acids, lipids & membranes 12.1-12.5 28 Coenzymes & vitamins 15.1-15.4 JP, Mar 1 MIDTERM EXAM #2 4:00-4:50pm Rooms TBA 175 points JP, Mar 2 Cell structure & organelles: nucleus, mitochondria & chloroplasts 12.6 18.1,19.1 4 Cell membranes & vesicles, RER, Golgi, lysosomes, micro-tubules & -filaments.
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