BISC 330 Spring 2011 Lecture 7

BISC 330 Spring 2011 Lecture 7 - BISC 330L: Biochemistry...

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BISC 330L: Biochemistry Spring Semester 2011 USC Lecture: Wed, 26 January 2011 1. More Chapter 2 material… Review Tertiary Structure Quaternary Structure Predicting α/β character
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Tertiary Structure Shows conformation of the whole polypeptide Stabilized by noncovalent bonds Can be studied by X-ray crystallography Proteins can be: fibrous (long and extended) globular (blobs) Ras
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Example of αβ Barrel Tertiary Structure Triosphosphate Isomerase (Fig. 16.4)
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Examples of Protein Tertiary Structures Ferritin (mainly α) F.A. Binding Protein (mainly β) Myoglobin (mainly α) Green Fluorescent Protein (mainly β) [Ser-Tyr-Gly]
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http://www.tsienlab.ucsd.edu/Images.htm Agar Plate of Fluorescent Bacteria Colonies
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Amino acid distribution and protein localization
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Zinc Finger Motif : Zinc ion of each finger is coordinated to two cysteines and two histidines Cysteines are part of two stranded beta sheet on one side Histidines are part of short alpha helix on opposite side Are spaced apart and project into successive major grooves Example is TFIIIA bound to DNA Complex of GLI and DNA
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Example is TFIIIA bound to DNA has 9 zinc finger motifs first zinc finger protein to be discovered
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This note was uploaded on 02/15/2012 for the course BISC 330L taught by Professor Petruska,tower during the Spring '07 term at USC.

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BISC 330 Spring 2011 Lecture 7 - BISC 330L: Biochemistry...

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