BISC 330 Spring 2011 Lecture 11

BISC 330 Spring 2011 Lecture 11 - BISC 330L: Biochemistry...

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BISC 330L: Biochemistry Spring Semester 2011 USC Lecture 11: Friday, 04 February 2011 1. Chapter 4: Flow of Genetic Information ¾ Review RNA/DNA structure ¾ Watson Crick proposal ¾ Current events in biochemistry
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Chapter 4: DNA, RNA, and the Flow of Genetic Information DNA RNA PROTEIN PROTEIN
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The Watson Crick Proposal •D N A composed of two chains • Two chains spiral around each other •S u g a r phosphate backbone on the outside •B a s e s situated inside double helix; perpendicular to long axis •M a j o r and minor grooves •O n e turn of helix / 10 nucleotides • Two chains are complementary and antiparallel •H bonds between bases • Pyrimidines always pair with purines
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Importance of Watson Crick Model 5’ 3’ 3’ 5’ Determining the structure had TWO important outcomes: 1. Gave rise to obvious and testable hypotheses about how genetic information could be stored and duplicated. 2. Gave rise to the starting point for the development of techniques to study DNA
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Erwin Chargaff showed that base composition (%) varies from organism to organism. Organism A T C G E. coli 40 40 10 10 Human 30 30 20 20 Mycobacterium 15 15 35 35 Chargaff’s Rules: %A = %T and %G = %C BUT : (%A + %T) did NOT equal the (%G + %C)
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The General Structure of the Nucleotide ¾ The sugar in all nucleotides is a pentose sugar ¾ DNA and RNA each have four types of bases ¾ Without the phosphate group, it would be called a “nucleoside” Base P O Sugar P P
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Ribose vs. Deoxyribose RNA DNA
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The Bases DNA bases: 2 purines (A,G) and 2 pyrimidines (C,T). RNA bases: 2 purines (A,G) and 2 pyrimidines (C,U).
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This note was uploaded on 02/15/2012 for the course BISC 330L taught by Professor Petruska,tower during the Spring '07 term at USC.

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BISC 330 Spring 2011 Lecture 11 - BISC 330L: Biochemistry...

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